ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2004
Interleukin-6 promoter polymorphism is associated with bone quality assessed by calcaneus ultrasound and previous fractures in a cohort of 75-year-old women.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Association of IL-6 174G/C (rs1800795) and 572C/G (rs1800796) polymorphisms with risk of osteoporosis: a meta-analysis.BMC musculoskeletal disorders · 2020Pooled it
- Association of IL-6 G-174C polymorphism with bone mineral density.Journal of bone and mineral metabolism · 2014Pooled it
- Association between interleukin-6 gene polymorphisms and bone mineral density: a meta-analysis.Genetic testing and molecular biomarkers · 2013Pooled it
- Article
- Circulating MicroRNA Expression, Vitamin D, and Hypercortisolism as Predictors of Osteoporosis in Elderly Postmenopausal Women.Disease markers · 2021Article
- The association between interleukin 6 -174 G/C gene polymorphism and the risk of osteoporosis: A meta-analysis.Journal of Taibah University Medical Sciences · 2017Article
- Effect of interleukin-6 polymorphism on fracture risk.International journal of clinical and experimental medicine · 2015Article
- Frequencies of interleukin-6, GST and progesterone receptor gene polymorphisms in postmenopausal women with low bone mineral density.Sao Paulo medical journal = Revista paulista de medicina · 2014Article
- IL6-174G/C polymorphism and fracture risk.International journal of clinical and experimental medicine · 2014Article
- Association between health-service use and multiplex genetic testing.Genetics in medicine : official journal of the American College of Medical Genetics · 2012Article
- The genetic pleiotropy of musculoskeletal aging.Frontiers in physiology · 2012Article
- Low appendicular muscle mass is correlated with femoral neck bone mineral density loss in postmenopausal women.BMC musculoskeletal disorders · 2011Article
- Review
- Genetics of bone loss in rheumatoid arthritis--role of vitamin D receptor polymorphisms.Rheumatology (Oxford, England) · 2009Review
- Genetics of the musculoskeletal system: a pleiotropic approach.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2008Article
- Molecular genetic studies of gene identification for osteoporosis: a 2004 update.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2006Review
- Association tests of interleukin-6 (IL-6) and type II tumor necrosis factor receptor (TNFR2) genes with bone mineral density in Caucasians using a re-sampling approach.Human genetics · 2005Article
- Frailty and hormones.Reviews in endocrine & metabolic disorders · 2005Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interleukin 6 (IL-6) is a multifunctional cytokine and a potent stimulator of bone resorption and has been implicated in the pathogenesis of osteoporosis in postmenopausal women. The aim of this study was to investigate if a functional IL-6 promoter polymorphism (-174) was related to bone mass and fractures in a cohort consisting of 964 postmenopausal Caucasian women aged 75 years. Bone mineral density (BMD; g/cm2) of the femoral neck, lumbar spine and total body was measured using dual energy X-ray absorptiometry (DXA). Quantitative ultrasound (QUS) was also measured in the calcaneus and quantified as speed of sound (SOS; m/s), broadband ultrasound attenuation (BUA; dB/MHz), and stiffness index (SI). IL-6 genotypes was determined by restriction fragment length polymorphism (RFLP) using the restriction enzyme NlaIII. The frequencies of the different IL-6 genotypes were 27.5% (GG), 47.9% (GC), 24.6% (CC). The IL-6 polymorphism (presence of G) was independently related to a lower stiffness (beta=-0.07; P=0.03) and BUA (beta=-0.08; P=0.02), but not to BMD at any site measured by DXA. In the cohort, 420 subjects (44%) reported at least one fracture during their lifetime, and 349 (36%) reported at least one fracture after the age of 50. Using binary logistic regression, the IL-6 polymorphism (presence of G) was significantly related to an increased risk of a previous fracture during life (odds ratio 1.46, 95% CI 1.08-1.97) and to an increased risk of a fracture occurring after 50 years of age (odds ratio 1.37, 95% CI 1.004-1.88). The risk was further increased for fractures grouped as osteoporotic fractures (odds ratio 1.67, 95% CI 1.14-2.45), including forearm fractures (odds ratio 1.59, 95% CI 1.05-2.40). In conclusion, presence of G allele in the IL-6 promoter polymorphism at position -174 is independently related to previous fractures in postmenopausal women. This association may be related primarily to an altered bone quality identified by QUS and not a lower bone mass. This is also the first demonstration of association of IL-6 gene polymorphism to calcaneal QUS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.