ArticleJournal of clinical immunology2004
A role of fas-associated death domain (FADD) in increased apoptosis in aged humans.
Article in Journal of clinical immunology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Article
- Therapeutic Promises of Bioactive Linarin, a Glycosylated Flavonoid: A Comprehensive Review With Mechanistic Insight.Journal of tropical medicine · 2025Review
- Die Hard: Necroptosis and its Impact on Age-Dependent Neuroinflammatory Diseases.Frontiers in cell death · 2024Article
- Omega-3 Alpha-Linolenic Fatty Acid Affects the Level of Telomere Binding Protein TRF1 in Porcine Skeletal Muscle.Animals : an open access journal from MDPI · 2020Article
- Role of Endogenous Glucocorticoids in Cancer in the Elderly.International journal of molecular sciences · 2018Review
- Integrative Bioinformatics and Functional Analyses of GEO, ENCODE, and TCGA Reveal FADD as a Direct Target of the Tumor Suppressor BRCA1.International journal of molecular sciences · 2018Article
- Molecular changes associated with increased TNF-α-induced apoptotis in naïve (TImmunity & ageing : I & A · 2018Article
- PKR Activation Favors Infectious Pancreatic Necrosis Virus Replication in Infected Cells.Viruses · 2016Article
- Dual Regulation of Cell Death and Cell Survival upon Induction of Cellular Stress by Isopimara-7,15-Dien-19-Oic Acid in Cervical Cancer, HeLa Cells In vitro.Frontiers in pharmacology · 2016Article
- Host resistance and immune responses in advanced age.Clinics in geriatric medicine · 2007Review
- Immunosupportive therapies in aging.Clinical interventions in aging · 2007Review
- A paradox of immunodeficiency and inflammation in human aging: lessons learned from apoptosis.Immunity & ageing : I & A · 2006Article
- Life and death of lymphocytes: a role in immunesenescence.Immunity & ageing : I & A · 2005Article
- Will telomere erosion lead to a loss of T-cell memory?Nature reviews. Immunology · 2004Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Fas-associated death domain (FADD) is an adapter protein that is recruited to the death-inducing signaling complex (DISC) during signaling via death receptors. FADD is a common conduit in both CD95-mediated and TNF-R-mediated apoptosis. In aging, T cells show increased susceptibility to death receptor-induced apoptosis. Therefore, in this investigation, we have examined the role of FADD in increased TNF-alpha-induced apoptosis of lymphocytes from aged humans. Our study shows that FADD expression is increased in lymphocytes from aged humans as compared to those from young subjects. Furthermore, transfection of aged lymphocytes with FADD dominant negative (FADD dn) plasmid resulted in the reduction of TNF-induced apoptosis in aged lymphocytes to a level comparable to that of young subjects. In addition, overexpression of FADD by transfection of lymphocytes from young subjects with wild-type FADD (FADD wt) resulted in increased apoptosis of young lymphocytes to a level comparable to that of young subjects. These data suggest that FADD plays an important role in increased apoptosis in aged lymphocytes signaled via TNF-R.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.