ArticleJournal of bacteriology2004
A -1 ribosomal frameshift in the transcript that encodes the major head protein of bacteriophage A2 mediates biosynthesis of a second essential component of the capsid.
Article in Journal of bacteriology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Folding the unfoldable 2: using AlphaFold and ESMFold to explore spurious proteins.Bioinformatics advances · 2026Article
- PRFect: a tool to predict programmed ribosomal frameshifts in prokaryotic and viral genomes.BMC bioinformatics · 2024Article
- Galaxy and Apollo as a biologist-friendly interface for high-quality cooperative phage genome annotation.PLoS computational biology · 2020Article
- Isolation and characterisation of novel phages infecting Lactobacillus plantarum and proposal of a new genus, "Silenusvirus".Scientific reports · 2020Article
- Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use.Nucleic acids research · 2016Review
- Structural proteins ofBacteriophage · 2016Article
- Two Phages, phiIPLA-RODI and phiIPLA-C1C, Lyse Mono- and Dual-Species Staphylococcal Biofilms.Applied and environmental microbiology · 2015Article
- Role of the Pre-neck Appendage Protein (Dpo7) from Phage vB_SepiS-phiIPLA7 as an Anti-biofilm Agent in Staphylococcal Species.Frontiers in microbiology · 2015Article
- Exposing the secrets of two well-known Lactobacillus casei phages, J-1 and PL-1, by genomic and structural analysis.Applied and environmental microbiology · 2014Article
- Functional genomic analysis of two Staphylococcus aureus phages isolated from the dairy environment.Applied and environmental microbiology · 2009Article
- Isolation of new Stenotrophomonas bacteriophages and genomic characterization of temperate phage S1.Applied and environmental microbiology · 2008Article
- Genome sequence and characteristics of Lrm1, a prophage from industrial Lactobacillus rhamnosus strain M1.Applied and environmental microbiology · 2008Article
- A second case of -1 ribosomal frameshifting affecting a major virion protein of the Lactobacillus bacteriophage A2.Journal of bacteriology · 2005Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The two major capsid proteins of Lactobacillus bacteriophage A2 share their amino termini. The smaller of these (gp5A) results from translation of orf5 and proteolytic processing after residue 123. The larger form (gp5B) originates through a -1 ribosomal frameshift at the penultimate codon of orf5 mRNA, resulting in a product that is 85 amino acids longer than gp5A. Frameshifting needs two cis-acting elements: a slippery region with the sequence C CCA AAA (0 frame), and a stem-loop that begins 9 nucleotides after the end of the slippery sequence. Mutations introduced in the slippery sequence suppress the frameshift. Similarly, deletion of the second half of the stem-loop results in drastic reduction of frameshifting. Both gp5A and gp5B appear to be essential for phage viability, since lysogens harboring prophages that produce only one or the other protein become lysed upon induction with mitomycin C, though no viable phage progeny are observed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.