ArticleMolecular and cellular biology2004
The oligo(A) tail on histone mRNA plays an active role in translational silencing of histone mRNA during Xenopus oogenesis.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- SLBP-independent control of maternal histone mRNA.bioRxiv : the preprint server for biology · 2026Article
- Maternal histone mRNAs are uniquely processed through polyadenylation in a Stem-Loop Binding Protein (SLBP) dependent manner.Nucleic acids research · 2025Article
- Identification and characterization of histones inNAR genomics and bioinformatics · 2021Article
- Determining degradation intermediates and the pathway of 3' to 5' degradation of histone mRNA using high-throughput sequencing.Methods (San Diego, Calif.) · 2019Review
- Oocyte-specific maternal Slbp2 is required for replication-dependent histone storage and early nuclear cleavage in zebrafish oogenesis and embryogenesis.RNA (New York, N.Y.) · 2018Article
- EnD-Seq and AppEnD: sequencing 3' ends to identify nontemplated tails and degradation intermediates.RNA (New York, N.Y.) · 2015Article
- Histones: sequestered by Jabba in fatty storehouse.Current biology : CB · 2012Article
- Metabolism and regulation of canonical histone mRNAs: life without a poly(A) tail.Nature reviews. Genetics · 2008Review
- SLIP1, a factor required for activation of histone mRNA translation by the stem-loop binding protein.Molecular and cellular biology · 2008Article
- Stem-loop binding protein expressed in growing oocytes is required for accumulation of mRNAs encoding histones H3 and H4 and for early embryonic development in the mouse.Developmental biology · 2008Article
- Review
- Histone gene expression and histone mRNA 3' end structure in Caenorhabditis elegans.BMC molecular biology · 2007Article
- The stem-loop binding protein regulates translation of histone mRNA during mammalian oogenesis.Developmental biology · 2005Article
- Control of messenger RNA fate by RNA-binding proteins: an emphasis on mammalian spermatogenesis.Journal of andrologyReview
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Metazoan replication-dependent histone mRNAs end in a stem-loop sequence. The one known exception is the histone mRNA in amphibian oocytes, which has a short oligo(A) tail attached to the stem-loop sequence. Amphibian oocytes also contain two proteins that bind the 3' end of histone mRNA: xSLBP1, the homologue of the mammalian SLBP, and xSLBP2, which is present only in oocytes. xSLBP2 is an inhibitor of histone mRNA translation, while xSLBP1 activates translation. The short A tail on histone mRNAs appears at stage II to III of oogenesis and is present on histone mRNAs throughout the rest of oogenesis. At oocyte maturation, the oligo(A) tail is removed and the xSLBP2 is degraded, resulting in the activation of translation of histone mRNA. Both SLBPs bind to the stem-loop with the oligo(A) tail with similar affinities. Reporter mRNAs ending in the stem-loop with or without the oligo(A) tail are translated equally well in a reticulocyte lysate, and their translation is stimulated by the presence of xSLBP1. In contrast, translation of the reporter mRNA with an oligo(A) tail is not activated in frog oocytes in response to the presence of xSLBP1. These results suggest that the oligo(A) tail is an active part of the translation repression mechanism that silences histone mRNA during oogenesis and that its removal is part of the mechanism that activates translation.
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