ArticleMolecular and cellular biology2004
In vitro targeting reveals intrinsic histone tail specificity of the Sin3/histone deacetylase and N-CoR/SMRT corepressor complexes.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
- HDAC3 in Alzheimer's Disease: established evidence, unresolved questions, and translational priorities.Molecular biology reports · 2026Review
- Selective targeting of cortactin tandem repeat acetylation by human lysine deacetylases.The FEBS journal · 2026Article
- Hierarchical regulation of cerebellar neurogenesis by Sin3A-mediated gene repression.bioRxiv : the preprint server for biology · 2025Article
- Article
- A Novel CRISPR Interference Effector Enabling Functional Gene Characterization with Synthetic Guide RNAs.The CRISPR journal · 2022Article
- The roles of histone deacetylases in kidney development and disease.Clinical and experimental nephrology · 2021Review
- SETD5-Coordinated Chromatin Reprogramming Regulates Adaptive Resistance to Targeted Pancreatic Cancer Therapy.Cancer cell · 2020Article
- Loss of HDAC3 contributes to meiotic defects in aged oocytes.Aging cell · 2019Article
- Co-repressor, co-activator and general transcription factor: the many faces of the Sin3 histone deacetylase (HDAC) complex.The Biochemical journal · 2018Review
- Aberrant Monoaminergic System in Thyroid Hormone Receptor-β Deficient Mice as a Model of Attention-Deficit/Hyperactivity Disorder.The international journal of neuropsychopharmacology · 2015Article
- Tristetraprolin represses estrogen receptor α transactivation in breast cancer cells.The Journal of biological chemistry · 2014Article
- Erasers of histone acetylation: the histone deacetylase enzymes.Cold Spring Harbor perspectives in biology · 2014Review
- The role of histone acetylation in memory formation and cognitive impairments.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Review
- HDAC3 and the molecular brake pad hypothesis.Neurobiology of learning and memory · 2011Review
- Deacetylase inhibitors dissociate the histone-targeting ING2 subunit from the Sin3 complex.Chemistry & biology · 2010Article
- Defective histone acetylation is responsible for the diminished expression of cyclooxygenase 2 in idiopathic pulmonary fibrosis.Molecular and cellular biology · 2009Article
- New insights into the functions and regulation of the transcriptional corepressors SMRT and N-CoR.Cell division · 2009Article
- Histone deacetylase 3 localizes to the mitotic spindle and is required for kinetochore-microtubule attachment.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- HDAC3: taking the SMRT-N-CoRrect road to repression.Oncogene · 2007Review
- Involvement of the SMRT/NCoR-HDAC3 complex in transcriptional repression by the CNOT2 subunit of the human Ccr4-Not complex.The Biochemical journal · 2006Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The histone code is among others established via differential acetylation catalyzed by histone acetyltransferases (HATs) and histone deacetylases (HDACs). To unambiguously determine the histone tail specificity of HDAC-containing complexes, we have established an in vitro system consisting of nucleosomal templates reconstituted with hyperacetylated histones or recombinant histones followed by acetylation with native SAGA or NuA4. Selective targeting of the mammalian Sin3/HDAC and N-CoR/SMRT corepressor complexes by using specific chimeric repressors created a near physiological setting to assess their histone tail specificity. Recruitment of the Sin3/HDAC complex to nucleosomal templates preacetylated with SAGA or NuA4 resulted in deacetylation of histones H3 and H4, whereas recruitment of N-CoR/SMRT resulted in deacetylation of histone H3 only. These results provide solid evidence that HDAC-containing complexes display distinct, intrinsic histone tail specificities and hence may function differently to regulate chromatin structure and transcription.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.