ArticleThe Biochemical journal2004
A functional polymeric immunoglobulin receptor in chicken (Gallus gallus) indicates ancient role of secretory IgA in mucosal immunity.
Article in The Biochemical journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 129 citations in OpenAlex.
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- Orally delivered chitosan-basedFrontiers in immunology · 2026Article
- Comprehensive analysis of blood proteome response to necrotic enteritis in broiler chicken.Veterinary research · 2025Article
- Kinetics of pIgR and IgM immune responses in snakehead (Channa argus) to inactivated Aeromonas hydrophila via immersion and intraperitoneal injection.Scientific reports · 2025Article
- Antigen specificity affects analysis of natural antibodies.Frontiers in immunology · 2024Article
- Effect of glutamine on the systemic innate immune response in broiler chickens challenged with Salmonella pullorum.BMC veterinary research · 2023Article
- Dietary Macleaya cordata extract supplementation improves the growth performance and gut health of broiler chickens with necrotic enteritis.Journal of animal science and biotechnology · 2023Article
- Analysis of Polymeric Immunoglobulin Receptor Expression in Olive Flounder (Development & reproduction · 2023Article
- Effects of Dietary Supplementation with Glutamine on the Immunity and Intestinal Barrier Gene Expression in Broiler Chickens Infected withAnimals : an open access journal from MDPI · 2022Article
- Comparative Analysis of theInternational journal of molecular sciences · 2022Article
- Expression characteristics of polymeric immunoglobulin receptor in Bactrian camel (Camelus bactrianus) lungs.PloS one · 2022Article
- Evolutionary analyses of polymeric immunoglobulin receptor (pIgR) in the mammals reveals an outstanding mutation rate in the lagomorphs.Frontiers in immunology · 2022Article
- Effects of age on immune function in broiler chickens.Journal of animal science and biotechnology · 2021Article
- Immunoglobulins in teleosts.Immunogenetics · 2021Review
- Differential Response of the Chicken Trachea to Chronic Infection with Virulent Mycoplasma gallisepticum Strain Ap3AS and Vaxsafe MG (Strain ts-304): a Transcriptional Profile.Infection and immunity · 2020Article
- Microbiome and pathogen interaction with the immune system.Poultry science · 2020Review
- Article
- Effect of dietary oridonin supplementation on growth performance, gut health, and immune response of broilers infected withIrish veterinary journal · 2018Article
- Biophysical and Biochemical Characterization of Avian Secretory Component Provides Structural Insights into the Evolution of the Polymeric Ig Receptor.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Effect of Diclazuril on the Bursa of Fabricius Morphology and SIgA Expression in Chickens Infected with Eimeria tenella.The Korean journal of parasitology · 2015Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Animals are continuously threatened by pathogens entering the body through natural openings. Here we show that in chicken ( Gallus gallus ), secretory IgA (sIgA) protects the epithelia lining these natural cavities. A gene encoding a chicken polymeric Ig receptor ( GG-pIgR ), a key component of sIgA, was identified, and shown to be expressed in the liver, intestine and bursa of Fabricius. All motifs involved in pIgR function are present, with a highly conserved Ig-binding motif in the first Ig-like domain. Physical association of GG-pIgR with pIgA in bile and intestine demonstrates that this protein is a functional receptor. Thus, as shown for mammals, this receptor interacts with J-chain-containing polymeric IgA (pIgA) at the basolateral epithelial cell surface resulting in transcytosis and subsequent cleavage of the pIgR, releasing sIgA in the mucosal lumen. Interestingly, the extracellular portion of GG-pIgR protein comprises only four Ig-like domains, in contrast with the five domain structure found in mammalian pIgR genes. The second Ig-like domain of mammalian pIgR does not have an orthologous domain in the chicken gene. The presence of pIgR in chicken suggests that this gene has evolved before the divergence of birds and reptiles, indicating that secretory Igs may have a prominent role in first line defence in various non-mammalian species.
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