ArticleNeurochemical research2004
The anion exchanger as an osmolyte channel in the skate erythrocyte.
Article in Neurochemical research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 14 citations in OpenAlex.
- Thrombin increases hyposmotic taurine efflux and accelerates ICI-swell and RVD in 3T3 fibroblasts by a src-dependent EGFR transactivation.Pflugers Archiv : European journal of physiology · 2008Article
- A conductive pathway generated from fragments of the human red cell anion exchanger AE1.The Journal of physiology · 2007Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regulatory volume decrease occurs in fish erythrocytes by the release of osmolytes via a channel involving the anion exchanger (AE), also known as band 3. This review focuses primarily on work done on red blood cells from the skate (Raja erinacea) to further understand the activation, regulation and identification of this osmolyte channel. A model is proposed in which the reduction in intracellular ionic strength that occurs with increased cell volume may change the interaction between AE dimers and other cytoplasmic proteins (band 4.1 and ankyrin), promoting the formation of a tetrameric osmolyte channel. Phosphorylation by two tyrosine kinases, p72syk and p56lyn, is linked to this oligomerization. The skate AE has been recently cloned, resulting in three different isoforms, one of which, skAE1, when expressed in Xenopus oocytes, demonstrates taurine transport.
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Registered trials
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