ArticleJournal of human genetics2004
Rapid isolation of viral integration site reveals frequent integration of HTLV-1 into expressed loci.
Article in Journal of human genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 30 citations in OpenAlex.
- Diversity of Integration Sites of Bovine Leukemia Virus (BLV) and Roles of Genes Related to Development of BLV-Induced Lymphoma in a Large Cohort.International journal of molecular sciences · 2026Article
- Intron-oriented HTLV-1 integration in an adult T-cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA.FEBS letters · 2025Article
- Review
- Genome-wide target profiling of piggyBac and Tol2 in HEK 293: pros and cons for gene discovery and gene therapy.BMC biotechnology · 2011Article
- The host genomic environment of the provirus determines the abundance of HTLV-1-infected T-cell clones.Blood · 2011Article
- Expression profiles of adult T-cell leukemia-lymphoma and associations with clinical responses to zidovudine and interferon alpha.Leukemia & lymphoma · 2010Article
- Proviral loads and clonal expansion of HTLV-1-infected cells following vertical transmission: a 10-year follow-up of children in Jamaica.Intervirology · 2009Article
- HTLV-1 integration into transcriptionally active genomic regions is associated with proviral expression and with HAM/TSP.PLoS pathogens · 2008Article
- Human T-cell leukemia virus type 1 integration target sites in the human genome: comparison with those of other retroviruses.Journal of virology · 2007Article
- TCR variable gene involvement in chromosome inversion between 14q11 and 14q24 in adult T-cell leukemia.Journal of human genetics · 2006Article
- Correction of chromosomal mutation and random integration in embryonic stem cells with helper-dependent adenoviral vectors.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Matrix attachment regions as targets for retroviral integration.Virology journal · 2005Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although there is tight association of the human T-cell leukemia virus type-1 (HTLV-1) with adult T-cell leukemia/lymphoma (ATLL), it has remained unresolved whether the HTLV-1 integration into the host genome has any role in the development of this disease. We isolated a total of 58 HTLV-1 integration sites using newly developed, adaptor-ligated PCR from 33 ATLL patients and five ATLL cell lines. We compared our data as well as the previously reported ones with the complete human genomic sequence for the location of its placement, structure, and expression of genes nearby the integration site. The chromosomal target for integration was selected at random, but the integration favorably occurred within the transcription units; more than 59.5% of total integration was observed within the transcriptional unit. All inserted genes by HTLV-1 integration were expressed in normal T cells. Upregulation of genes due to viral integration was found in two out of nine ATLL cases; about 4.4- and 102-fold elevated ankyrin-1 ( ANK-1) and gephyrin ( GPHN) gene expressions were observed, respectively. These data suggest that the preferential integration of HTLV-1 into an expressed locus occasionally causes deregulation of corresponding gene, which may lead to leukemogenesis of a fraction of ATLL.
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