Trial reportEuropean journal of applied physiology2004
Effect of intermittent hypoxia on oxygen uptake during submaximal exercise in endurance athletes.
Trial report in European journal of applied physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 127 citations in OpenAlex.
- The Effects of Intermittent Hypoxic Training Strategies on Maximal Oxygen Uptake in Healthy Humans: A Meta-analysis with Meta-regression.Sports medicine (Auckland, N.Z.) · 2026Pooled it
- Sea-level exercise performance following adaptation to hypoxia: a meta-analysis.Sports medicine (Auckland, N.Z.) · 2009Pooled it
- Efficacy of Shenqi Pollen Capsules for High-Altitude Deacclimatization Syndrome via Suppression of the Reoxygenation Injury and Inflammatory Response.Journal of immunology research · 2019Trial
- Trial
- Analysis of high-altitude de-acclimatization syndrome after exposure to high altitudes: a cluster-randomized controlled trial.PloS one · 2013Trial
- Effects of intermittent hypoxia on SaO(2), cerebral and muscle oxygenation during maximal exercise in athletes with exercise-induced hypoxemia.European journal of applied physiology · 2008Trial
- Respiratory control during air-breathing exercise in humans following an 8 h exposure to hypoxia.Respiratory physiology & neurobiology · 2008Trial
- Influences of short-term hypobaric hypoxia training on body composition, maximal aerobic power, and pro-oxidant/antioxidant balance in healthy young adults: a randomized controlled pilot study.Physical activity and nutrition · 2025Article
- Comparison of the Effects of Endurance Training Conducted in Conditions of Normoxia and Artificial Hypoxia in Patients After Myocardial Infarction.Journal of clinical medicine · 2025Article
- Effects of concurrent heat and hypoxic training on cycling anaerobic capacity in men.Scientific reports · 2024Article
- 7.0T cardiac magnetic resonance imaging of right ventricular function in rats with high-altitude deacclimatization.Annals of translational medicine · 2023Article
- Physiological and performance effects of live high train low altitude training for elite endurance athletes: A narrative review.Current research in physiology · 2023Review
- The Effect of Normobaric Hypoxia in Middle- and/or Long-Distance Runners: Systematic Review.Biology · 2022Review
- Repeated sprint training under hypoxia improves aerobic performance and repeated sprint ability by enhancing muscle deoxygenation and markers of angiogenesis in rugby sevens.European journal of applied physiology · 2022Article
- Effects of Interval Training Under Hypoxia on Hematological Parameters, Hemodynamic Function, and Endurance Exercise Performance in Amateur Female Runners in Korea.Frontiers in physiology · 2022Article
- The Use of Artificial Hypoxia in Endurance Training in Patients after Myocardial Infarction.International journal of environmental research and public health · 2021Article
- The Effects of Intermittent Hypoxic Training on Anaerobic and Aerobic Power in Boxers.International journal of environmental research and public health · 2020Article
- Determining the time needed for workers to acclimatize to hypoxia.International journal of biometeorology · 2020Article
- Intermittent hypoxia modulates redox homeostasis, lipid metabolism associated inflammatory processes and redox post-translational modifications: Benefits at high altitude.Scientific reports · 2020Article
- Interval Hypoxic Training Enhances Athletic Performance and Does Not Adversely Affect Immune Function in Middle- and Long-Distance Runners.International journal of environmental research and public health · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of the present study was to clarify the following: (1) whether steady state oxygen uptake (VO(2)) during exercise decreases after short-term intermittent hypoxia during a resting state in trained athletes and (2) whether the change in VO(2) during submaximal exercise is correlated to the change in endurance performance after intermittent hypoxia. Fifteen trained male endurance runners volunteered to participate in this study. Each subject was assigned to either a hypoxic group (n=8) or a control group (n=7). The hypoxic group spent 3 h per day for 14 consecutive days in normobaric hypoxia [12.3 (0.2)% inspired oxygen]. The maximal and submaximal exercise tests, a 3,000-m time trial, and resting hematology assessments at sea level were conducted before and after intermittent normobaric hypoxia. The athletes in both groups continued their normal training in normoxia throughout the experiment. VO(2) during submaximal exercise in the hypoxic group decreased significantly (P<0.05) following intermittent hypoxia. In the hypoxic group, the 3,000-m running time tended to improve (P=0.06) after intermittent hypoxia, but not in the control group. Neither peak VO(2) nor resting hematological parameters were changed in either group. There were significant (P<0.05) relationships between the change in the 3,000-m running time and the change in VO(2) during submaximal exercise after intermittent hypoxia. The results from the present study suggest that the enhanced running economy resulting from intermittent hypoxia could, in part, contribute to improved endurance performance in trained athletes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.