Evidence map›Paper›PMID 14991304›Full record

ArticleJournal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology2004

Divergent actions of serotonin receptor activation during fictive swimming in frog embryos.

D L McLean, K T Sillar

Abstract read
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In one paragraph

Article in Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Parallel evolution of serotonergic neuromodulation underlies independent evolution of rhythmic motor behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013
    Article
  7. Neural mechanisms underlying the evolvability of behaviour.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011
    Review
  8. Opposing aminergic modulation of distinct spinal locomotor circuits and their functional coupling during amphibian metamorphosis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009
    Article
  9. Gasping activity in vitro: a rhythm dependent on 5-HT2A receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

D L McLeanSchool of Biology, Bute Medical Buildings, University of St Andrews, KY16 9TS St Andrews, Fife, Scotland.
K T Sillar
University of St Andrews · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We have investigated the pharmacology underlying locomotor system responses to serotonin (5-HT) in embryos of the frog, Rana temporaria, to provide a comparison to studies in embryos of its close relative, Xenopus laevis. Our findings suggest that two divergent mechanisms underlie the modulation of locomotion by 5-HT in Rana. Bath-applied 5-HT or 5-carboxamidotyptamine, a 5-HT(1,5A,7) receptor agonist, can modulate fictive swimming in a dose-dependent manner, increasing burst durations and cycle periods. However, activation of 5-HT(1,7) receptors with R8-OHDPAT or 8-OHDPAT fails to mimic 5-HT, and in some cases exerts exactly the opposite response; decreasing burst durations and cycle periods. Elevating endogenous 5-HT levels by blocking re-uptake with clomipramine transiently increases burst durations. The receptors involved in this endogenous response include 5-HT(1A) receptors, as in Xenopus, but also 5-HT(7) receptors. However, like the 8-OHDPAT enantiomers, prolonged re-uptake inhibition can result in a motor response in the opposite direction to exogenous 5-HT. This effect is not reversed by 5-HT(1A) and/or 5-HT(7) receptor antagonism, implicating 5-HT(1B/1D) receptors. Remarkably, antagonism of these receptors using methiothepin unmasks a dose-dependent response to clomipramine, reminiscent of exogenous 5-HT. Our data suggest that 5-HT(1A,7) and 5-HT(1B/1D) receptors act as gain-setters of burst durations, whilst 5-HT(5A) receptors are involved in the effects of bath-applied 5-HT on locomotion.

Indexed as

8-Hydroxy-2-(di-n-propylamino)tetralinAction PotentialsAnimalsAxonsCentral Nervous SystemClomipramineDose-Response Relationship, DrugEmbryo, NonmammalianMotor NeuronsMuscle ContractionMuscle, SkeletalRana temporariaReceptor, Serotonin, 5-HT1AReceptors, SerotoninSelective Serotonin Reuptake InhibitorsSerotonin8-Hydroxy-2-(di-n-propylamino)tetralinClomipramineReceptor, Serotonin, 5-HT1AReceptors, SerotoninSelective Serotonin Reuptake InhibitorsSerotoninserotonin 7 receptorSerotonin AntagonistsSerotonin Receptor Agonists

Identifiers

PMID14991304
OpenAlexW2169629741

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.