ArticleJournal of virology2004
Cul7/p185/p193 binding to simian virus 40 large T antigen has a role in cellular transformation.
Article in Journal of virology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 83 citations in OpenAlex.
- Review
- Article
- Structure of CRL7Nature structural & molecular biology · 2022Article
- Identification and verification of the prognostic value of CUL7 in colon adenocarcinoma.Frontiers in immunology · 2022Article
- Functional Domains of the Early Proteins and Experimental and Epidemiological Studies Suggest a Role for the Novel Human Polyomaviruses in Cancer.Frontiers in microbiology · 2022Review
- Ubiquitin ligases in cancer: Functions and clinical potentials.Cell chemical biology · 2021Review
- Immortalization of primary sheep embryo kidney cells.In vitro cellular & developmental biology. Animal · 2021Article
- Article
- Merkel cell polyomavirus small tumour antigen activates the p38 MAPK pathway to enhance cellular motility.The Biochemical journal · 2020Article
- The Biology and Clinical Features of Cutaneous Polyomaviruses.The Journal of investigative dermatology · 2019Review
- Merkel cell polyomavirus Tumor antigens expressed in Merkel cell carcinoma function independently of the ubiquitin ligases Fbw7 and β-TrCP.PLoS pathogens · 2019Article
- Activation of the DNA Damage Response by RNA Viruses.Biomolecules · 2016Review
- Merkel cell polyomavirus: molecular insights into the most recently discovered human tumour virus.Cancers · 2014Article
- Inhibition of Cullin-RING E3 ubiquitin ligase 7 by simian virus 40 large T antigen.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Inhibition of post-transcriptional RNA processing by CDK inhibitors and its implication in anti-viral therapy.PloS one · 2014Article
- Two independent regions of simian virus 40 T antigen increase CBP/p300 levels, alter patterns of cellular histone acetylation, and immortalize primary cells.Journal of virology · 2013Article
- Merkel cell polyomavirus large T antigen disrupts lysosome clustering by translocating human Vam6p from the cytoplasm to the nucleus.The Journal of biological chemistry · 2011Article
- Interaction and co-localization of JC virus large T antigen and the F-box protein β-transducin-repeat containing protein.Virology · 2011Article
- Multiple DNA damage signaling and repair pathways deregulated by simian virus 40 large T antigen.Journal of virology · 2010Article
- Ubiquitin ligase cullin 7 induces epithelial-mesenchymal transition in human choriocarcinoma cells.The Journal of biological chemistry · 2010Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Simian virus 40 large T antigen (TAg) is a viral oncoprotein that can promote cellular transformation. TAg's transforming activity results in part by binding and inactivating key tumor suppressors, including p53 and the retinoblastoma protein (pRb). We have identified a TAg-associated 185-kDa protein that has significant homology to the cullin family of E3 ubiquitin ligases. TAg binds to an SCF-like complex that contains p185/Cul7, Rbx1, and the F box protein Fbw6. This SCF-like complex binds to an N-terminal region of TAg. Several p185/Cul7-binding-deficient mutants of TAg were generated that retained binding to pRb and p53 and were capable of overcoming Rb-mediated repression of E2F transcription. Despite binding to pRb and p53, these p185/Cul7-binding-defective mutants of TAg were unable to transform primary mouse embryo fibroblasts. Cells expressing p185/Cul7-binding-defective mutants of TAg were unable to grow to high density or grow in an anchorage-independent manner as determined by growth in soft agar. Considering the significance of other TAg-interacting proteins in regulation of the cell cycle, p185/Cul7 may also regulate an important growth control pathway.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.