Trial reportThe Journal of physiology2004
Different vasodilator responses of human arms and legs.
Trial report in The Journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 151 citations in OpenAlex.
- L-Citrulline Supplementation Improves Arterial Blood Flow and Muscle Oxygenation during Handgrip Exercise in Hypertensive Postmenopausal Women.Nutrients · 2024Trial
- Trial
- Folic acid ingestion improves skeletal muscle blood flow during graded handgrip and plantar flexion exercise in aged humans.American journal of physiology. Heart and circulatory physiology · 2017Trial
- L-Arginine supplementation does not enhance blood flow and muscle performance in healthy and physically active older women.European journal of nutrition · 2016Trial
- Vasomotor and fibrinolytic responses to kinin receptor agonists in the atherosclerotic human lower limb.Heart and vessels · 2012Trial
- Effects of limb posture on reactive hyperemia.European journal of applied physiology · 2011Trial
- Impact of chronic intermittent external compressions on forearm blood flow capacity in humans.European journal of applied physiology · 2011Trial
- Single limb exercise induces femoral artery remodeling and improves blood flow in the hemiparetic leg poststroke.Stroke · 2009Trial
- Ageing reduces nitric-oxide- and prostaglandin-mediated vasodilatation in exercising humans.The Journal of physiology · 2007Trial
- Glucose clearance is higher in arm than leg muscle in type 2 diabetes.The Journal of physiology · 2005Trial
- Microvascular dysfunction in chronic kidney disease: A feasibility study.Clinical physiology and functional imaging · 2026Article
- Article
- Characteristics of Muscle Oxygenation of the Upper and Lower Limb During Moderate-Intensity Upper Limb Crank Exercise: A Near-Infrared Spectroscopy Study.Advances in experimental medicine and biology · 2026Article
- Effects of Compression Garments on Muscle Oxygen Saturation Recovery in the Upper Limbs Using Near-Infrared Spectroscopy.Journal of functional morphology and kinesiology · 2025Article
- Using Wavelet Analysis of Blood Flow Oscillations to Investigate Differences in Skin Blood Flow Regulations Between the Upper and Lower Limbs.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024Article
- Mechanistic, participant, and movement-related factors that contribute to low-flow-mediated constriction.European journal of applied physiology · 2023Review
- Association between Femoral Artery Flow-Mediated Dilation and Muscle Oxygen Saturation Parameters in Healthy, Young Individuals.Journal of cardiovascular development and disease · 2023Article
- Pilot study of optical coherence tomography angiography-derived microvascular metrics in hands and feet of healthy and diabetic people.Scientific reports · 2023Article
- Tracking peripheral vascular function for six months in young adults following SARS-CoV-2 infection.Physiological reports · 2022Article
- Acute heat exposure improves microvascular function in skeletal muscle of aged adults.American journal of physiology. Heart and circulatory physiology · 2022Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Forearm vascular responses to intra-arterial infusions of endothelium-dependent and -independent vasodilators have been thoroughly characterized in humans. While the forearm is a well-established experimental model for studying human vascular function, it is of limited consequence to systemic cardiovascular control owing to its small muscle mass and blood flow requirements. In the present study we determined whether these responses could be generalized to the leg. Based upon blood pressure differences between the leg and arm during upright posture, we hypothesized that the responsiveness to endothelium-dependent vasodilators would be greater in the forearm than the leg. Brachial and femoral artery blood flow (Q, ultrasound Doppler) at rest and during intra-arterial infusions of endothelium-dependent (acetylcholine and substance P) and -independent (sodium nitroprusside) vasodilators were measured in eight healthy men (22-27 years old). Resting blood flows in the forearm before infusion of acetylcholine, substance P or sodium nitroprusside were 25 +/- 4, 30 +/- 7 and 29 +/- 5 ml min(-1), respectively, and in the leg were 370 +/- 32, 409 +/- 62 and 330 +/- 30 ml min(-1), respectively. At the highest infusion rate of acetylcholine (16 microg (100 ml tissue)(-1) min(-1)) there was a greater (P < 0.05) increase in Q to the forearm (1864 +/- 476%) than to the leg (569 +/- 86%). Similarly, at the highest infusion rate of substance P (125 pg (100 ml tissue)(-1) min(-1)) there was a greater (P < 0.05) increase in Q to the forearm (911 +/- 286%) than to the leg (243 +/- 58%). The responses to sodium nitroprusside (1 microg (100 ml tissue)(-1) min(-1)) were also greater (P < 0.05) in the forearm (925 +/- 164%) than in the leg (326 +/- 65%). These data indicate that vascular responses to both endothelium-dependent and -independent vasodilator agents are blunted in the leg compared to the forearm.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.