ArticleJournal of clinical pathology2004
Clinical evaluation of the polymerase chain reaction for the rapid diagnosis of tuberculosis.
Article in Journal of clinical pathology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Surgical correction of severe cervical kyphosis secondary to tuberculoid Pott's disease: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- Superiority of TB-PCR Over Conventional and Immunologic Tests for Diagnosing Tuberculosis in Small Bronchoscopic Non-Malignant Specimens.Infection and drug resistance · 2025Article
- Rapid Detection of Mycobacterium Tuberculosis Using a Novel Point-of-Care BZ TB/NTM NALF Assay: Integrating LAMP and LFIA Technologies.Diagnostics (Basel, Switzerland) · 2023Article
- Comparison of Conventional Methods with Newer Diagnostic Modalities to Detect Genital Tuberculosis in Infertile Women.Journal of obstetrics and gynaecology of India · 2022Article
- Clinical performance of quantitative PCR for the molecular identification of skeletal tuberculosis from formalin-fixed paraffin-embedded tissues.BMC infectious diseases · 2022Article
- A Rare Presentation of Central Nervous System Tuberculomas in an Immunocompetent Patient.Hawai'i journal of health & social welfare · 2022Article
- Tuberculosis of ischial tuberosity as a rare cause of gluteal pain: A case series of 9 patients with review of literature.Journal of clinical orthopaedics and trauma · 2022Article
- The diagnostic impact of implementing a molecular-based algorithm to standard mycobacterial screening at a reference laboratory with an intermediate prevalence for non-respiratory samples.Saudi journal of biological sciences · 2021Article
- Concomitant hepatic tuberculosis and hepatocellular carcinoma: a case report and review of the literature.BMC surgery · 2021Review
- Microbial burden and inflammasome activation in amniotic fluid of patients with preterm prelabor rupture of membranes.Journal of perinatal medicine · 2020Article
- Identification of Mycobacterium tuberculosis isolated from culture-negative pulmonary and extra-pulmonary samples in cases of suspected tuberculosis.GMS hygiene and infection control · 2019Article
- Evaluation of rapid GeneXpert MTB/RIF method using DNA tissue specimens of vertebral bones in patients with suspected spondylitis TB.Journal of orthopaedics · 2017Article
- Tuberculous Spondylitis: A Report of Different Clinical Scenarios and Literature Update.Case reports in medicine · 2017Article
- Serum enolase-2, high-sensitivity C-reactive protein, and serum cholesterol in smear-positive drug-naïve pulmonary tuberculosis.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2017Article
- Neuron-specific enolase as a novel biomarker reflecting tuberculosis activity and treatment response.The Korean journal of internal medicine · 2016Article
- Role of alpha-crystallin, early-secreted antigenic target 6-kDa protein and culture filtrate protein 10 as novel diagnostic markers in osteoarticular tuberculosis.Journal of orthopaedic translation · 2016Review
- A Rare Case of Pott's Disease (Spinal Tuberculosis) Mimicking Metastatic Disease in the Southern Region of Denmark.The American journal of case reports · 2016Article
- Differentiation of Mycobacterium tuberculosis complex from non-tubercular mycobacteria by nested multiplex PCR targeting IS6110, MTP40 and 32kD alpha antigen encoding gene fragments.BMC infectious diseases · 2016Article
- Metabolomic Profiling of Plasma from Patients with Tuberculosis by Use of Untargeted Mass Spectrometry Reveals Novel Biomarkers for Diagnosis.Journal of clinical microbiology · 2015Article
- Identification of specific metabolites in culture supernatant of Mycobacterium tuberculosis using metabolomics: exploration of potential biomarkers.Emerging microbes & infections · 2015Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsUse of the polymerase chain reaction for the detection of Mycobacterium tuberculosis (TB PCR) as a basis for making clinical decisions on the initiation of antituberculosis treatment was studied.
methodsA retrospective study involving a cohort of 155 patients being investigated for tuberculosis in an infectious disease consultation service was undertaken. TB PCR was performed on pulmonary and extrapulmonary specimens from these patients. The sensitivity of TB PCR was analysed.
resultsOf the 155 patients, 144 fitted the clinical diagnosis of tuberculosis, and 112 of them were culture positive for M tuberculosis. Sixty (58.3%) patients with clinical features suggestive of tuberculosis received antituberculosis treatment based on positive TB PCR alone. Of 224 clinical specimens (138 pulmonary and 86 extrapulmonary) sent for TB PCR, 148 (99 pulmonary and 49 extrapulmonary) were positive in 117 patients. Of the 690 clinical specimens sent for culture, 279 were positive for M tuberculosis in 112 patients. The diagnostic sensitivity of TB PCR was 75.9% (85 of 112) and 81.3% (117 of 144) in patients with culture confirmed and clinically diagnosed tuberculosis, respectively. Using culture as the gold standard, the overall sensitivity of TB PCR was 78.3%, and for pulmonary and extrapulmonary specimens it was 82.3% and 72.0%, respectively.
conclusionsTB PCR is a rapid and reliable test in the diagnosis and management of tuberculosis.
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