ArticleJournal of clinical pathology2004
Pulmonary pathological features in coronavirus associated severe acute respiratory syndrome (SARS).
Article in Journal of clinical pathology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07380152 (Corticosteroid Treatment for Post-COVID-19 Persistent Interstitial Lung Disease), which is not on this map. Cited by 138 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Corticosteroid Treatment for Post-COVID-19 Persistent Interstitial Lung Disease
Who cites it
138 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Effectiveness of Pulmonary Rehabilitation in Interstitial Lung Disease, Including Coronavirus Diseases: A Systematic Review and Meta-analysis.Archives of physical medicine and rehabilitation · 2021Pooled it
- Autopsy findings in COVID-19-related deaths: a literature review.Forensic science, medicine, and pathology · 2021Pooled it
- Autopsy Tool in Unknown Diseases: The Experience with Coronaviruses (SARS-CoV, MERS-CoV, SARS-CoV-2).Medicina (Kaunas, Lithuania) · 2021Pooled it
- Pooled it
- A pilot trial of human amniotic fluid for the treatment of COVID-19.BMC research notes · 2021Trial
- ACE1 polymorphism and progression of SARS.Biochemical and biophysical research communications · 2004Trial
- Sputum cytology of patients with severe acute respiratory syndrome (SARS).Journal of clinical pathology · 2004Trial
- Pathogenesis and virulence of coronavirus disease: Comparative pathology of animal models for COVID-19.Virulence · 2024Review
- Small Airways Dysfunction and Lung Hyperinflation in Long COVID-19 Patients as Potential Mechanisms of Persistent Dyspnoea.Advances in respiratory medicine · 2024Article
- Long COVID symptoms after 8-month recovery: persistent static lung hyperinflation associated with small airway dysfunction.Respiratory research · 2024Observational
- Pulmonary Function, Computed Tomography Lung Abnormalities, and Small Airway Disease after COVID-19: 3-, 6-, and 9-Month Follow-Up.Journal of clinical medicine · 2024Article
- A case series of three patients with histologically proven post COVID-19 organizing pneumonia.Respirology case reports · 2023Article
- Mitigation of influenza-mediated inflammation by immunomodulatory matrix-bound nanovesicles.Science advances · 2023Article
- Review
- Celastrol: A lead compound that inhibits SARS-CoV-2 replication, the activity of viral and human cysteine proteases, and virus-induced IL-6 secretion.Drug development research · 2022Article
- Delayed lung function testing after COVID-19 to detect persistent lung function abnormalities - The DELTA - COVID-19 lung function study.Journal of family medicine and primary care · 2022Article
- Co-infection associated with SARS-CoV-2 and their management.Future science OA · 2022Review
- Lifestyle in Obese Individuals during the COVID-19 Pandemic.Healthcare (Basel, Switzerland) · 2022Article
- Lung function and radiological findings 1 year after COVID-19: a prospective follow-up.Respiratory research · 2022Observational
- Immune-based therapeutic approaches in COVID-19.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022Review
78 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSevere acute respiratory syndrome (SARS) became a worldwide outbreak with a mortality of 9.2%. This new human emergent infectious disease is dominated by severe lower respiratory illness and is aetiologically linked to a new coronavirus (SARS-CoV).
methodsPulmonary pathology and clinical correlates were investigated in seven patients who died of SARS in whom there was a strong epidemiological link. Investigations include a review of clinical features, morphological assessment, histochemical and immunohistochemical stainings, ultrastructural study, and virological investigations in postmortem tissue.
resultsPositive viral culture for coronavirus was detected in most premortem nasopharyngeal aspirate specimens (five of six) and postmortem lung tissues (two of seven). Viral particles, consistent with coronavirus, could be detected in lung pneumocytes in most of the patients. These features suggested that pneumocytes are probably the primary target of infection. The pathological features were dominated by diffuse alveolar damage, with the presence of multinucleated pneumocytes. Fibrogranulation tissue proliferation in small airways and airspaces (bronchiolitis obliterans organising pneumonia-like lesions) in subpleural locations was also seen in some patients.
conclusionsViable SARS-CoV could be isolated from postmortem tissues. Postmortem examination allows tissue to be sampled for virological investigations and ultrastructural examination, and when coupled with the appropriate lung morphological changes, is valuable to confirm the diagnosis of SARS-CoV, particularly in clinically unapparent or suspicious but unconfirmed cases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.