ArticleBiophysical journal2004
Effects of intermediate bound states in dynamic force spectroscopy.
Article in Biophysical journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed.
- A compartment size-dependent selective threshold limits mutation accumulation in hierarchical tissues.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Stochastic simulation of single-molecule pulling experiments.The European physical journal. E, Soft matter · 2014Article
- Rupture of multiple catch-slip bonds: Two-state two-pathway catch-slip bonds.The European physical journal. E, Soft matter · 2013Article
- A transformation for the mechanical fingerprints of complex biomolecular interactions.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Biophysical description of multiple events contributing blood leukocyte arrest on endothelium.Frontiers in immunology · 2013Article
- Rupture of multiple receptor-ligand bonds: bimodal distribution of bond rupture force.The European physical journal. E, Soft matter · 2012Article
- Compaction and tensile forces determine the accuracy of folding landscape parameters from single molecule pulling experiments.Physical review letters · 2011Article
- Complex unfolding kinetics of single-domain proteins in the presence of force.Biophysical journal · 2010Article
- Methods and estimations of uncertainties in single-molecule dynamic force spectroscopy.European biophysics journal : EBJ · 2009Article
- Energy landscape of chelated uranyl: antibody interactions by dynamic force spectroscopy.Biophysical journal · 2007Article
- Dissecting subsecond cadherin bound states reveals an efficient way for cells to achieve ultrafast probing of their environment.FEBS letters · 2007Article
- Dynamics of single DNA looping and cleavage by Sau3AI and effect of tension applied to the DNA.Biophysical journal · 2006Article
- Theoretical analysis of single-molecule force spectroscopy experiments: heterogeneity of chemical bonds.Biophysical journal · 2006Article
- Forced-unfolding and force-quench refolding of RNA hairpins.Biophysical journal · 2006Article
- DNA looping by two-site restriction endonucleases: heterogeneous probability distributions for loop size and unbinding force.Nucleic acids research · 2006Article
- The solution to the streptavidin-biotin paradox: the influence of history on the strength of single molecular bonds.Biophysical journal · 2005Article
- Multi-step fibrinogen binding to the integrin (alpha)IIb(beta)3 detected using force spectroscopy.Biophysical journal · 2005Article
- The two-pathway model for the catch-slip transition in biological adhesion.Biophysical journal · 2005Article
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
We revisit some aspects of the interpretation of dynamic force spectroscopy experiments. The standard theory predicts that the typical unbinding force f* is linearly proportional to the logarithm of the loading rate r when a single energy barrier controls the unbinding process. For a more complex situation of N barriers, it predicts at most N linear segments for the f* vs. log(r) curve, each segment characterizing a different barrier. Here we extend this existing picture using a refined approximation, provide a more general analytical formula, and show that in principle up to N(N + 1) / 2 segments can show up experimentally. As a consequence, the determination of the positions and even the number of the energy barriers from the experimental data can be ambiguous. A further possible consequence of a multiple-barrier landscape is a bimodal or multimodal distribution of the unbinding force at certain loading rates, a feature recently observed experimentally.
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