Evidence map›Paper›PMID 14989419›Full record

ArticleSchizophrenia bulletin2003

Commentary: Progress, issues, and implications of prodromal research: an inside view.

Thomas H McGlashan

Abstract readComment
PubMed Publisher
In one paragraph

Article in Schizophrenia bulletin, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Multiomic blood correlates of genetic risk identify presymptomatic disease alterations.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  4. Striatum-related functional activation during reward- versus punishment-based learning in psychosis risk.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019
    Article
  5. Review
  6. Review
  7. Article
  8. Toward a world consensus on prevention of schizophrenia.Dialogues in clinical neuroscience · 2005
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Thomas H McGlashanDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.

Funding

EARLY DETECTION AND INTERVENTION IN PSYCHOSISK05MH001654 · NIMH · YALE UNIVERSITY · PI MCGLASHAN, THOMAS HAMEL · 1999 to 2003
$500k
NIMH NIH HHS MH01654
6 · The paper itself

Abstract

This issue of the Schizophrenia Bulletin focuses around research in the prodromal phase of severe mental illness, largely schizophrenia. The years since the last Bulletin issue on early detection and intervention have witnessed success at identifying the prodrome prospectively, positive initial data about treating prodromal symptoms and delaying psychosis onset, and hopeful data about elucidating the pathophysiology of psychosis through the prodrome. In this overview I will comment on some of the opportunities and challenges generated by this new line of research. Themes include the recruitment of prodromal subjects, characteristics of prodromal samples thus far collected, the process of conversion to psychosis in these samples, minimizing false positive prodromal subjects, dosing of drug treatments in prodromal clinical trials, treatment practice implications of prodromal research, defining conversion to psychosis prospectively, and screening, assessing, and naming the prodrome. It is concluded that prodromal research holds much promise but will require the formal collaboration of many investigators and the availability of resources for sustained efforts to recruit what amounts to an incidence sample.

Indexed as

Antipsychotic AgentsClinical Trials as TopicDiagnosis, DifferentialDisease ProgressionHumansPsychiatric Status Rating ScalesPsychometricsReproducibility of ResultsResearchRisk FactorsSchizophreniaSchizotypal Personality DisorderAntipsychotic Agents

Identifiers

PMID14989419

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.