ArticleSchizophrenia bulletin2003
Proton magnetic resonance spectroscopy in first episode psychosis and ultra high-risk individuals.
Article in Schizophrenia bulletin, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 123 citations in OpenAlex.
- [Magnetic resonance spectroscopy in schizophrenia. Possibilities and limitations].Der Radiologe · 2005Pooled it
- Neurometabolites in schizophrenia and bipolar disorder - a systematic review and meta-analysis.Psychiatry researchPooled it
- 7T magnetic resonance spectroscopic imaging of subcortical neurometabolites across antipsychotic treatment in acutely symptomatic early-phase schizophrenia spectrum disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- N-Acetylaspartate and Choline Metabolites in Cortical and Subcortical Regions in Clinical High Risk Relative to Healthy Control Subjects: An Exploratory 7T MRSI Study.International journal of molecular sciences · 2023Article
- A Review of Potential Neuroimaging Biomarkers of Schizophrenia-Risk.Journal of psychiatry and brain science · 2023Article
- Prefrontal and Striatal Gamma-Aminobutyric Acid Levels and the Effect of Antipsychotic Treatment in First-Episode Psychosis Patients.Biological psychiatry · 2018Article
- Metabolic Abnormalities in the Hippocampus of Patients with Schizophrenia: A 3D Multivoxel MR Spectroscopic Imaging Study at 3T.AJNR. American journal of neuroradiology · 2016Article
- Dietary supplementation with n-3 fatty acids from weaning limits brain biochemistry and behavioural changes elicited by prenatal exposure to maternal inflammation in the mouse model.Translational psychiatry · 2015Article
- Impaired context processing as a potential marker of psychosis risk state.Psychiatry research · 2014Article
- T2 relaxation effects on apparent N-acetylaspartate concentration in proton magnetic resonance studies of schizophrenia.Psychiatry research · 2013Review
- Proton magnetic resonance spectroscopy (H-MRS) in chronic schizophrenia. A single-voxel study in three regions involved in a pathogenetic theory.The neuroradiology journal · 2013Article
- The psychosis high-risk state: a comprehensive state-of-the-art review.JAMA psychiatry · 2013Review
- N-Acetyl-Aspartate Level is Decreased in the Prefrontal Cortex in Subjects At-Risk for Schizophrenia.Frontiers in psychiatry · 2013Article
- Whither the attenuated psychosis syndrome?Schizophrenia bulletin · 2012Article
- Different duration of at-risk mental state associated with neurofunctional abnormalities. A multimodal imaging study.Human brain mapping · 2012Article
- Gray matter volumetric abnormalities associated with the onset of psychosis.Frontiers in psychiatry · 2012Article
- Proton magnetic resonance spectroscopy and thought disorder in childhood schizophrenia.Schizophrenia research · 2011Article
- Cortical thickness reduction in individuals at ultra-high-risk for psychosis.Schizophrenia bulletin · 2011Article
- Cognitive control deficits in schizophrenia: mechanisms and meaning.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Review
- Structural MRI correlates for vulnerability and resilience to major depressive disorder.Journal of psychiatry & neuroscience : JPN · 2011Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The underlying neurobiology of emerging psychotic disorders is not well understood. Recent neuroimaging findings have suggested that some brain areas are affected prior to the onset of psychosis, while changes occur in other brain regions during the transition to illness. Further, previous research using magnetic resonance spectroscopy (MRS) has generally demonstrated that there are changes to the brain chemistry of patients with schizophrenia. However, it is unclear whether these changes are present prior to or at the onset of the disorder, and to what extent they are specific to schizophrenia. In this study, we assessed the left medial temporal and left dorsolateral prefrontal regions of 56 patients in their first episode of a psychotic disorder, 30 young people at ultra high-risk (UHR) of developing psychosis, and 21 healthy controls, using proton MRS. Six of the UHR group developed a first episode psychosis over the study period. No differences were identified between the first episode and control groups for any metabolite ratio in either region of interest. This may reflect intact neuronal circuits in the early phase of psychotic disorders. There were also no differences between the UHR and control groups for the medial temporal region. However, there was a significant elevation of the NAA/Creatine and the Choline/Creatine ratios in the dorsolateral prefrontal region of the UHR group, which was interpreted as a decline in creatine indicative of hypometabolism. This finding did not discriminate between those UHR individuals who later became psychotic and those who did not.
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