ReviewSchizophrenia bulletin2003
A review and new report of medial temporal lobe dysfunction as a vulnerability indicator for schizophrenia: a magnetic resonance imaging morphometric family study of the parahippocampal gyrus.
Review in Schizophrenia bulletin, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 136 citations in OpenAlex.
- Cortical Thickness Abnormalities at Different Stages of the Illness Course in Schizophrenia: A Systematic Review and Meta-analysis.JAMA psychiatry · 2022Pooled it
- Does Hippocampal Volume Predict Transition to Psychosis in a High-Risk Group? A Meta-Analysis.Frontiers in psychiatry · 2020Pooled it
- Role of the Primate Perirhinal Cortex in Memory and Emotional Regulation: Ontogeny and Early Insults.Medical research archives · 2026Article
- Independence-based causal discovery analysis reveals statistically non-significant regions to be functionally significant.bioRxiv : the preprint server for biology · 2025Article
- fMRI fluctuations within the language network are correlated with severity of hallucinatory symptoms in schizophrenia.Schizophrenia (Heidelberg, Germany) · 2023Article
- Multipronged investigation of morphometry and connectivity of hippocampal network in relation to risk for psychosis using ultrahigh field MRI.Schizophrenia research · 2023Article
- Activation of the left medial temporal gyrus and adjacent brain areas during affective theory of mind processing correlates with trait schizotypy in a nonclinical population.Social cognitive and affective neuroscience · 2023Article
- Medial temporal lobe contributions to resting-state networks.Brain structure & function · 2022Article
- Hearing voices in the head: Two meta-analyses on structural correlates of auditory hallucinations in schizophrenia.NeuroImage. Clinical · 2022Review
- Hyperactivity of caudate, parahippocampal, and prefrontal regions during working memory in never-medicated persons at clinical high-risk for psychosis.Schizophrenia research · 2016Article
- Alterations of lateral temporal cortical gray matter and facial memory as vulnerability indicators for schizophrenia: An MRI study in youth at familial high-risk for schizophrenia.Schizophrenia research · 2016Article
- Sex and laterality differences in parkinsonian impairment and transcranial ultrasound in never-treated schizophrenics and their first degree relatives in an Andean population.Schizophrenia research · 2015Article
- Reduced levels of vasopressin and reduced behavioral modulation of oxytocin in psychotic disorders.Schizophrenia bulletin · 2014Article
- Smoking status as a potential confounder in the study of brain structure in schizophrenia.Journal of psychiatric research · 2014Article
- Reduced parahippocampal cortical thickness in subjects at ultra-high risk for psychosis.Psychological medicine · 2014Article
- Altered amygdala connectivity within the social brain in schizophrenia.Schizophrenia bulletin · 2014Article
- Similar and different gray matter deficits in schizophrenia patients and their unaffected biological relatives.Frontiers in psychiatry · 2013Review
- Genetic variation in GAD1 is associated with cortical thickness in the parahippocampal gyrus.Journal of psychiatric research · 2013Article
- Hippocampal physiology, structure and function and the neuroscience of schizophrenia: a unified account of declarative memory deficits, working memory deficits and schizophrenic symptoms.Behavioral sciences (Basel, Switzerland) · 2013Review
- Using structural neuroimaging to make quantitative predictions of symptom progression in individuals at ultra-high risk for psychosis.Frontiers in psychiatry · 2013Article
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Authors and funding
10 authors at 7 institutions in 3 countries.
Funding
Abstract
A central question in schizophrenia research is which brain abnormalities are independent of psychosis and which evolve before and after psychosis begins. This question can be addressed by longitudinal neuroimaging studies beginning in the prodrome, but at present there is only one published study. We reviewed the literature on structural brain imaging in persons with chronic and first episode schizophrenia, nonpsychotic persons at genetic high risk, and persons thought to be at risk for imminent psychosis ("prodromal" persons). Medial temporal lobe (MTL), especially hippocampal, volume alterations are among the most robust brain vulnerabilities for schizophrenia. Because verbal declarative memory (VDM) deficits are prominent and the parahippocampal gyrus (PHG) is considered to be centrally involved with the hippocampus in VDM processing, we analyzed PHG data from a family study of schizophrenia. Patients with schizophrenia and nonpsychotic relatives from "multiplex" families (families with multiple persons with schizophrenia) had significantly smaller right parahippocampal anterior (PHa) volumes than controls. Marginally significant findings were observed for the left PHa. Unexpectedly, relatives from "simplex" families (families with only one person with schizophrenia) had significantly larger PH posterior volumes than controls and did not differ from controls on PHa. Results provide some support for the hypothesis that the vulnerability to schizophrenia includes abnormal volumes of the PHG. These data provide additional support for the hypothesis that some MTL abnormalities in schizophrenia are independent of psychosis, at least in families with presumably high genetic loading. Implications of genetic risk studies for prodromal research are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.