ArticleSchizophrenia bulletin2003
Prolonged untreated illness duration from prodromal onset predicts outcome in first episode psychoses.
Article in Schizophrenia bulletin, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 3 of them syntheses that pooled it.
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Who cites it
43 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Magnetic resonance imaging-based machine learning classification of schizophrenia spectrum disorders: a meta-analysis.Psychiatry and clinical neurosciences · 2024Pooled it
- Cognitive Predictors of Social and Occupational Functioning in Early Psychosis: A Systematic Review and Meta-analysis of Cross-Sectional and Longitudinal Data.Schizophrenia bulletin · 2021Pooled it
- Advancing study of cognitive impairments for antipsychotic-naïve psychosis comparing high-income versus low- and middle-income countries with a focus on urban China: Systematic review of cognition and study methodology.Schizophrenia research · 2020Pooled it
- Impact of prior pharmacotherapy on remission of psychotic depression in a randomized controlled trial.Journal of psychiatric research · 2011Trial
- Challenging the Minimum Effective Antipsychotic Dose During Maintenance: Implications From 10-Year Follow-Up of First Episode Psychosis.Frontiers in psychiatry · 2021Article
- Similarities and Differences in Associations Between Duration of Untreated Psychosis (DUP) and Demographic, Premorbid, and Symptom Severity Measures in Two Samples of First-Episode Psychosis Patients from Mexico and the United States.The Psychiatric quarterly · 2020Article
- Visual Cortical Alterations and their Association with Negative Symptoms in Antipsychotic-Naïve First Episode Psychosis.Psychiatry research · 2020Article
- Achieving the Lowest Effective Antipsychotic Dose for Patients with Remitted Psychosis: A Proposed Guided Dose-Reduction Algorithm.CNS drugs · 2020Review
- Duration of the psychosis prodrome.Schizophrenia research · 2020Article
- How Do Early Psychosis Services Define and Operationalize the Duration of Untreated Psychosis?The journal of behavioral health services & research · 2019Article
- Longitudinal trajectory of early functional recovery in patients with first episode psychosis.Schizophrenia research · 2019Article
- Discrimination and avoidance due to disability in Australia: evidence from a National Cross Sectional Survey.BMC public health · 2018Article
- Untreated illness and recovery in clients of an early psychosis intervention program: a 10-year prospective cohort study.Social psychiatry and psychiatric epidemiology · 2018Article
- Factor analysis of the Scale of Prodromal Symptoms: data from the Early Detection and Intervention for the Prevention of Psychosis Program.Early intervention in psychiatry · 2017Article
- Duration of attenuated positive and negative symptoms in individuals at clinical high risk: Associations with risk of conversion to psychosis and functional outcome.Journal of psychiatric research · 2016Article
- Duration of unspecific prodromal and clinical high risk states, and early help-seeking in first-admission psychosis patients.Social psychiatry and psychiatric epidemiology · 2015Article
- Neurocognition as a predictor of outcome in schizophrenia in the Northern Finland Birth Cohort 1966.Schizophrenia research. Cognition · 2015Article
- Clinical high risk and first episode schizophrenia: auditory event-related potentials.Psychiatry research · 2015Article
- A stratified model for psychosis prediction in clinical practice.Schizophrenia bulletin · 2014Article
- Frequency and pattern of childhood symptom onset reported by first episode schizophrenia and clinical high risk youth.Schizophrenia research · 2014Article
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Funding
Abstract
Several, although not all, studies suggest that prolonged duration of untreated illness (DUI) predicts poor outcome in psychotic disorders such as schizophrenia. It is unclear whether this association can be explained by factors such as baseline deficits or poor premorbid adjustment. First episode psychotic patients were evaluated at 1 and 2 years following baseline evaluations. Predictive measures showing significant correlations with outcome were entered in multiple regression analyses with Strauss-Carpenter scale (SC) and Global Assessment of Functioning scale (GAF) outcome scores as dependent variables. Illness duration computed from the onset of the prodrome (DUI-pro), used both as a dichotomous and as a continuous measure, highly significantly predicted both GAF and SC scores at 2 years. On the other hand, baseline functioning significantly predicted the 1-year but not the 2-year outcome. When Premorbid Adjustment Scale (PAS) scores were additionally entered into the analyses in a smaller subset, the relation between DUI-pro and the 2-year outcome scores remained significant. Significant associations were also seen between outcome and baseline neuropsychological deficits involving attention and memory. Further research is needed to examine whether prolonged untreated illness is simply associated with poor outcome or plays a causal role in relation to outcome. The latter, if true, would strongly support therapeutic intervention efforts in the prodromal and early psychotic phases of schizophrenia.
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