ArticleSchizophrenia bulletin2003
The assessment of "prodromal schizophrenia": unresolved issues and future directions.
Article in Schizophrenia bulletin, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinical high risk for psychosis in children and adolescents: a systematic review.European child & adolescent psychiatry · 2018Pooled it
- Glycine treatment of the risk syndrome for psychosis: report of two pilot studies.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2013Trial
- Subjective cognitive complaint in at-risk mental states.Schizophrenia research. Cognition · 2026Article
- Predicting new onset thought disorder in early adolescence with optimized deep learning implicates environmental-putamen interactions.medRxiv : the preprint server for health sciences · 2023Article
- Alterations in facial expressivity in youth at clinical high-risk for psychosis.Journal of abnormal psychology · 2019Article
- Can Peripheral Blood-Derived Gene Expressions Characterize Individuals at Ultra-high Risk for Psychosis?Computational psychiatry (Cambridge, Mass.) · 2017Article
- Abnormalities in brain white matter in adolescents with 22q11.2 deletion syndrome and psychotic symptoms.Brain imaging and behavior · 2017Article
- Psychotropic medication use in youth at high risk for psychosis: comparison of baseline data from two research cohorts 1998-2005 and 2008-2011.Schizophrenia research · 2013Article
- "To see or not to see: that is the question." The "Protection-Against-Schizophrenia" (PaSZ) model: evidence from congenital blindness and visuo-cognitive aberrations.Frontiers in psychology · 2013Article
- Deficient Suppression of Default Mode Regions during Working Memory in Individuals with Early Psychosis and at Clinical High-Risk for Psychosis.Frontiers in psychiatry · 2013Article
- HPA axis function and symptoms in adolescents at clinical high risk for schizophrenia.Schizophrenia research · 2012Article
- Ethical implications for clinical practice and future research in "at risk" individuals.Current pharmaceutical design · 2012Review
- Prediction and prevention of schizophrenia: what has been achieved and where to go next?World psychiatry : official journal of the World Psychiatric Association (WPA) · 2011Article
- Associations between psychotic-like symptoms and inattention/hyperactivity symptoms.Social psychiatry and psychiatric epidemiology · 2011Article
- "Attenuated psychotic symptoms syndrome" as a risk syndrome of psychosis, diagnosis in DSM-V: The debate.Indian journal of psychiatry · 2011Article
- The case for including Attenuated Psychotic Symptoms Syndrome in DSM-5 as a psychosis risk syndrome.Schizophrenia research · 2010Article
- Research in people with psychosis risk syndrome: a review of the current evidence and future directions.Journal of child psychology and psychiatry, and allied disciplines · 2010Review
- Pediatric bipolar disorder: evidence for prodromal states and early markers.Journal of child psychology and psychiatry, and allied disciplines · 2010Review
- Validity of the prodromal risk syndrome for first psychosis: findings from the North American Prodrome Longitudinal Study.Schizophrenia bulletin · 2009Article
- Memory-prediction errors and their consequences in schizophrenia.Neuropsychology review · 2009Review
Corrections and comments
- Commented on by
- Commented on by
- Commented on by
Authors and funding
5 authors.
Funding
Abstract
Because of the novelty of research with clinical high risk ("prodromal") patients, many unresolved issues exist concerning how the prodromal state is defined and measured. Data are presented from the Recognition and Prevention (RAP) program at the Zucker Hillside Hospital to address several outstanding questions. Baseline attenuated positive symptoms were rated in 42 putatively prodromal patients in the RAP program using the Scale of Prodromal Symptoms (SOPS). Followup data of 6 months or more were available on 34 of these subjects; 9 of these (26.5%) developed psychotic disorders. Patients who developed psychosis had significantly higher SOPS positive symptom scores at baseline than those who did not. Various thresholds, using both total SOPS positive symptom scores and highest single item score, significantly predicted transition to psychosis, which calls into question appropriate cutoffs for the distinction between health, prodromal status, and psychosis. The SOPS positive symptom "conceptual disorganization" was found to be significantly related to disorganized behavior but not to other positive symptoms or to psychotic outcome, suggesting the importance of examining dimensions of psychopathology. The dimensional quantification of prodromal symptom severity may be an important direction for future studies of the assessment of at-risk states.
Indexed as
Identifiers
14989409What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.