Molecular biology. HNFs--linking the liver and pancreatic islets in diabetes.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

16 citing papers in PubMed.

1. Mutational landscapes of HNF MODY gene products display a wide distribution with functional implications.Endocrine connections · 2025
   Review
2. The protein architecture and allosteric landscape of HNF4α.Frontiers in endocrinology · 2023
   Review
3. Expression of hepatocyte nuclear factor 4 alpha, wingless-related integration site, and β-catenin in clinical gastric cancer.World journal of clinical cases · 2022
   Article
4. NKX6.1 transcription factor: a crucial regulator of pancreatic β cell development, identity, and proliferation.Stem cell research & therapy · 2020
   Review
5. Novel Mechanisms for IGF-I Regulation by Glucagon in Carp Hepatocytes: Up-Regulation of HNF1α and CREB Expression via Signaling Crosstalk for IGF-I Gene Transcription.Frontiers in endocrinology · 2019
   Article
6. Polymorphism in microRNA-binding site in HNF1B influences the susceptibility of type 2 diabetes mellitus: a population based case-control study.BMC medical genetics · 2015
   Article
7. Pancreatic and duodenal homeobox gene 1 (Pdx1) down-regulates hepatic transcription factor 1 alpha (HNF1α) expression during reprogramming of human hepatic cells into insulin-producing cells.American journal of translational research · 2015
   Article
8. Modeling integrated cellular machinery using hybrid Petri-Boolean networks.PLoS computational biology · 2013
   Article
9. Functional analyses of the mutation nt-128 T→G in the hepatocyte nuclear factor-1α promoter region in Chinese diabetes pedigrees.Diabetic medicine : a journal of the British Diabetic Association · 2012
   Article
10. Proteomic analysis of native hepatocyte nuclear factor-4α (HNF4α) isoforms, phosphorylation status, and interactive cofactors.The Journal of biological chemistry · 2011
    Article
11. Distinct regulation of hepatic nuclear factor 1alpha by NKX6.1 in pancreatic beta cells.The Journal of biological chemistry · 2010
    Article
12. Structural basis of natural promoter recognition by a unique nuclear receptor, HNF4alpha. Diabetes gene product.The Journal of biological chemistry · 2008
    Article
13. Facilitating effects of berberine on rat pancreatic islets through modulating hepatic nuclear factor 4 alpha expression and glucokinase activity.World journal of gastroenterology · 2008
    Article
14. Proteomic screen defines the hepatocyte nuclear factor 1alpha-binding partners and identifies HMGB1 as a new cofactor of HNF1alpha.Nucleic acids research · 2008
    Article
15. Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteome.Proceedings of the National Academy of Sciences of the United States of America · 2006
    Article
16. New insights into the roles of insulin/IGF-I in the development and maintenance of beta-cell mass.Reviews in endocrine & metabolic disorders · 2005
    Review

Corrections and comments

• Comment on
  Control of pancreas and liver gene expression by HNF transcription factors.2004

Authors and funding

2 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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