ArticleProceedings of the National Academy of Sciences of the United States of America2004
The tissue plasminogen activator-plasmin system participates in the rewarding effect of morphine by regulating dopamine release.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 111 citations in OpenAlex.
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- Differential Brain and Cerebrospinal Fluid Proteomic Responses to Acute Prenatal Endotoxin Exposure.Molecular neurobiology · 2022Article
- A Glitch in the Matrix: The Role of Extracellular Matrix Remodeling in Opioid Use Disorder.Frontiers in integrative neuroscience · 2022Review
- The Fibrinolytic System: Mysteries and Opportunities.HemaSphere · 2021Review
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- Cell type-specific activation of mitogen-activated protein kinase in D1 receptor-expressing neurons of the nucleus accumbens potentiates stimulus-reward learning in mice.Scientific reports · 2018Article
- Inter-individual differences in serotonin and glutamate co-transmission reflect differentiation in context-induced conditioned 50-kHz USVs response after morphine withdrawal.Brain structure & function · 2018Article
- Morphine Withdrawal Increases Brain-Derived Neurotrophic Factor Precursor.Neurotoxicity research · 2017Article
- MiR-340 Regulates Fibrinolysis and Axon Regrowth Following Sciatic Nerve Injury.Molecular neurobiology · 2017Article
- Effects of Ethanol on Brain Extracellular Matrix: Implications for Alcohol Use Disorder.Alcoholism, clinical and experimental research · 2016Review
- Passenger mutations and aberrant gene expression in congenic tissue plasminogen activator-deficient mouse strains.Journal of thrombosis and haemostasis : JTH · 2016Article
- Looking Inside the Matrix: Perineuronal Nets in Plasticity, Maladaptive Plasticity and Neurological Disorders.Neurochemical research · 2016Review
- κ-opioid receptor as a key mediator in the regulation of appetitive 50-kHz ultrasonic vocalizations.Psychopharmacology · 2015Article
- Serum matrix metalloproteinase-9 levels and severity of symptoms in boys with attention deficit hyperactivity disorder ADHD/hyperkinetic disorder HKD.European child & adolescent psychiatry · 2015Article
- Depletion of perineuronal nets in the amygdala to enhance the erasure of drug memories.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Article
- Tissue plasminogen activator contributes to morphine tolerance and induces mechanical allodynia via astrocytic IL-1β and ERK signaling in the spinal cord of mice.Neuroscience · 2013Article
- Protease-activated receptor 1 (PAR1) coupling to G(q/11) but not to G(i/o) or G(12/13) is mediated by discrete amino acids within the receptor second intracellular loop.Cellular signalling · 2012Article
- Glutamate controls tPA recycling by astrocytes, which in turn influences glutamatergic signals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Roles of a novel molecule 'shati' in the development of methamphetamine-induced dependence.Current neuropharmacology · 2011Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tissue plasminogen activator (tPA) is a serine protease that catalyzes the conversion of plasminogen (plg) to plasmin, which in turn functions to degrade extracellular matrix proteins in the central nervous system. The tPA-plasmin system plays a role in synaptic plasticity and remodeling. Here we show that this protease system participates in the rewarding effects of morphine by acutely regulating morphine-induced dopamine release in the nucleus accumbens (NAcc). A single morphine treatment induced tPA mRNA and protein expression in a naloxone-sensitive manner, which was associated with an increase in the enzyme activity in the NAcc. The acute effect of morphine in inducing tPA expression was diminished after repeated administration. Morphine-induced conditioned place preference and hyperlocomotion were significantly reduced in tPA(-/-) and plg(-/-) mice, being accompanied by a loss of morphine-induced dopamine release in the NAcc. The defect of morphine-induced dopamine release and hyperlocomotion in tPA(-/-) mice was reversed by microinjections of either exogenous tPA or plasmin into the NAcc. Our findings demonstrate a previously undescribed function of the tPA-plasmin system in regulating dopamine release, which is involved in the rewarding effects of morphine.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.