ArticlePlant physiology2004
The pea gene LH encodes ent-kaurene oxidase.
Article in Plant physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 73 citations in OpenAlex.
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- Innovations in functional genomics and molecular breeding of pea: exploring advances and opportunities.aBIOTECH · 2024Review
- High-quality reference genome sequences of two coconut cultivars provide insights into evolution of monocot chromosomes and differentiation of fiber content and plant height.Genome biology · 2021Article
- No Home without Hormones: How Plant Hormones Control Legume Nodule Organogenesis.Plant communications · 2020Review
- De novo transcriptome assembly reveals high transcriptional complexity in Pisum sativum axillary buds and shows rapid changes in expression of diurnally regulated genes.BMC genomics · 2017Article
- Forward Genetics by Sequencing EMS Variation-Induced Inbred Lines.G3 (Bethesda, Md.) · 2017Article
- Probing the Single Key Amino Acid Responsible for the Novel Catalytic Function ofFrontiers in plant science · 2017Article
- Transcriptome Profiling to Understand the Effect of Citrus Rootstocks on the Growth of 'Shatangju' Mandarin.PloS one · 2017Article
- The role of gibberellins in improving the resistance of tebuconazole-coated maize seeds to chilling stress by microencapsulation.Scientific reports · 2016Article
- Functional characterization of ent-copalyl diphosphate synthase, kaurene synthase and kaurene oxidase in the Salvia miltiorrhiza gibberellin biosynthetic pathway.Scientific reports · 2016Article
- Higher sterol content regulated by CYP51 with concomitant lower phospholipid content in membranes is a common strategy for aluminium tolerance in several plant species.Journal of experimental botany · 2015Article
- Isolation and expression profiles of gibberellin metabolism genes in developing male and female cones of Pinus tabuliformis.Functional & integrative genomics · 2014Article
- Plant hormones in arbuscular mycorrhizal symbioses: an emerging role for gibberellins.Annals of botany · 2013Article
- The genes for gibberellin biosynthesis in wheat.Functional & integrative genomics · 2012Article
- Tissue-specific regulation of gibberellin biosynthesis in developing pea seeds.Plant physiology · 2011Article
- Comprehensive transcriptome analysis of the highly complex Pisum sativum genome using next generation sequencing.BMC genomics · 2011Article
- The extreme dwarf phenotype of the GA-sensitive mutant of sunflower, dwarf2, is generated by a deletion in the ent-kaurenoic acid oxidase1 (HaKAO1) gene sequence.Plant molecular biology · 2011Article
- Mutation of rice BC12/GDD1, which encodes a kinesin-like protein that binds to a GA biosynthesis gene promoter, leads to dwarfism with impaired cell elongation.The Plant cell · 2011Article
- Dwarf plants of diploid Medicago sativa carry a mutation in the gibberellin 3-beta-hydroxylase gene.Plant cell reports · 2008Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pea (Pisum sativum) homolog, PsKO1, of the Arabidopsis GA3 gene was isolated. It codes for a cytochrome P450 from the CYP701A subfamily and has ent-kaurene oxidase (KO) activity, catalyzing the three step oxidation of ent-kaurene to ent-kaurenoic acid in the gibberellin (GA) biosynthetic pathway when expressed in yeast (Saccharomyces cerevisiae). PsKO1 is encoded by the LH gene because in three independent mutant alleles, lh-1, lh-2, and lh-3, PsKO1 has altered sequence, and the lh-1 allele, when expressed in yeast, failed to metabolize ent-kaurene. The lh mutants of pea are GA deficient and have reduced internode elongation and root growth. One mutant (lh-2) also causes a large increase in seed abortion. PsKO1 (LH) is expressed in all tissues examined, including stems, roots, and seeds, and appears to be a single-copy gene. Differences in sensitivity to the GA synthesis inhibitor, paclobutrazol, between the mutants appear to result from the distinct nature of the genetic lesions. These differences may also explain the tissue-specific differences between the mutants.
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