ArticleDevelopment genes and evolution2004
Isolation and evaluation of dextral-specific and dextral-enriched cDNA clones as candidates for the handedness-determining gene in a freshwater gastropod, Lymnaea stagnalis.
Article in Development genes and evolution, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Heterochirality results from reduction of maternalZoological letters · 2019Article
- Molecular evolution of glycoside hydrolase genes in the Western corn rootworm (Diabrotica virgifera virgifera).PloS one · 2014Article
- A conserved set of maternal genes? Insights from a molluscan transcriptome.The International journal of developmental biology · 2014Article
- Chiral speciation in terrestrial pulmonate snails.PloS one · 2012Article
- Dextral and sinistral Amphidromus inversus (Gastropoda: Pulmonata: Camaenidae) produce dextral sperm.Zoomorphology · 2011Article
- Expression patterns of engrailed and dpp in the gastropod Lymnaea stagnalis.Development genes and evolution · 2008Article
- The convoluted evolution of snail chirality.Die Naturwissenschaften · 2005Review
- One of the main forces that advance all fields of scientific inquiry is the establishment of unifying principles.Development genes and evolution · 2004Article
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3 authors.
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Abstract
The handedness of gastropods is genetically determined. The freshwater gastropod Lymnaea stagnalis is a normally dextral species, but contains minor sinistral populations. The gene responsible for handedness determination in this species is predicted to function maternally and specifically in the dextral-ovipositing snail. In this study, we used differential screening and cDNA subtraction to isolate eight "dextral genes" that are specific to, or enriched in, the dextral-ovipositing strains of L. stagnalis. These genes were promising candidates for the handedness-determining gene. In order to determine whether the true handedness-determining gene was among them, we tested for genetic correlations between the level of expression of each dextral gene and the handedness phenotype, i.e., the chirality of the next generation offspring, by using a collection of backcross F2 progeny of F1 offspring from crosses between dextral and sinistral strains. Although the present study could not identify the handedness-determining molecules, this approach appears to be promising for the isolation of such developmentally important genes.
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