ArticleDevelopment genes and evolution2004
A description of the Mei2-like protein family; structure, phylogenetic distribution and biological context.
Article in Development genes and evolution, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 0 citations in OpenAlex.
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- RNA-Binding Proteins in Dinoflagellates.International journal of molecular sciences · 2026Review
- Transcriptomic Analysis of Cold-Induced Temporary Cysts in Marine DinoflagellateInternational journal of molecular sciences · 2025Article
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- Same, same but different: Exploring Plasmodium cell division during liver stage development.PLoS pathogens · 2023Review
- ZmTE1 promotes plant height by regulating intercalary meristem formation and internode cell elongation in maize.Plant biotechnology journal · 2022Article
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- Control of Grain Size and Weight by the GSK2-LARGE1/OML4 Pathway in Rice.The Plant cell · 2020Article
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- Transcriptomic Analyses ofFrontiers in microbiology · 2017Article
- Transcriptomic Analysis of Thermally StressedFrontiers in plant science · 2017Article
- A Plasmodium yoelii Mei2-Like RNA Binding Protein Is Essential for Completion of Liver Stage Schizogony.Infection and immunity · 2016Article
- Major transitions in the evolution of early land plants: a bryological perspective.Annals of botany · 2012Review
- The function of the RNA-binding protein TEL1 in moss reveals ancient regulatory mechanisms of shoot development.Plant molecular biology · 2012Article
- Structure and vascular tissue expression of duplicated TERMINAL EAR1-like paralogues in poplar.Planta · 2010Article
- Spo5/Mug12, a putative meiosis-specific RNA-binding protein, is essential for meiotic progression and forms Mei2 dot-like nuclear foci.Eukaryotic cell · 2006Article
- Stem cell signalling networks in plants.Plant molecular biology · 2006Review
- The Arabidopsis-mei2-like genes play a role in meiosis and vegetative growth in Arabidopsis.The Plant cell · 2006Article
- The Arabidopsis Mei2 homologue AML1 binds AtRaptor1B, the plant homologue of a major regulator of eukaryotic cell growth.BMC plant biology · 2005Article
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Authors and funding
4 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Schizosaccharomyces pombe Mei2 gene encodes an RNA recognition motif (RRM) protein that stimulates meiosis upon binding a specific non-coding RNA and subsequent accumulation in a "mei2-dot" in the nucleus. We present here the first systematic characterization of the family of proteins with characteristic Mei2-like amino acid sequences. Mei2-like proteins are an ancient eukaryotic protein family with three identifiable RRMs. The C-terminal RRM (RRM3) is unique to Mei2-like proteins and is the most highly conserved of the three RRMs. RRM3 also contains conserved sequence elements at its C-terminus not found in other RRM domains. Single copy Mei2-like genes are present in some fungi, in alveolates such as Paramecium and in the early branching eukaryote Entamoeba histolytica, while plants contain small families of Mei2-like genes. While the C-terminal RRM is highly conserved between plants and fungi, indicating conservation of molecular mechanisms, plant Mei2-like genes have changed biological context to regulate various aspects of developmental pattern formation.
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