Trial reportJournal of cancer research and clinical oncology2004
A single nucleotide polymorphism in the MMP-1 promoter is correlated with histological differentiation of gastric cancer.
Trial report in Journal of cancer research and clinical oncology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- A Matrix Metalloproteinase-1 Polymorphism,Disease markers · 2018Pooled it
- Association between promoters polymorphisms of matrix metalloproteinases and risk of digestive cancers: a meta-analysis.Journal of cancer research and clinical oncology · 2013Pooled it
- Pooled it
- Matrix Metalloproteinases inInternational journal of molecular sciences · 2022Review
- Role of extra cellular proteins in gastric cancer progression and metastasis: an update.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2020Review
- Contribution of matrix metalloproteinases-1 genotypes to gastric cancer susceptibility in Taiwan.BioMedicine · 2017Article
- Association between promoter polymorphisms of matrix metalloproteinase-1 and risk of gastric cancer.OncoTargets and therapy · 2015Article
- Article
- Article
- Single-nucleotide polymorphisms of matrix metalloproteinases and their inhibitors in gastrointestinal cancer.World journal of gastrointestinal oncology · 2011Article
- Identification of a cigarette smoke-responsive region in the distal MMP-1 promoter.American journal of respiratory cell and molecular biology · 2009Article
- No association of the matrix metalloproteinase 1 promoter polymorphism with susceptibility to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma in northern China.World journal of gastroenterology · 2005Article
- A single nucleotide polymorphism in the MMP-9 promoter affects tumor progression and invasive phenotype of gastric cancer.Journal of cancer research and clinical oncology · 2005Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeMatrix metalloproteinase-1 (MMP-1) plays a key role in cancer invasion and metastasis by degradation of extracellular matrix (ECM) and basement membrane barriers. The 1G/2G single nucleotide polymorphism (SNP) in the MMP-1 promoter at position -1607 bp has been reported to affect the transcriptional activity. In the light of these findings, we investigated whether this SNP in the MMP-1 promoter is associated with the development, differentiation, and progression of gastric cancer.
methodsThe 215 gastric cancer patients and 166 controls were used in this study. The SNP of the MMP-1 promoter was analyzed by PCR-RFLP and sequencing. The genotype frequency was compared between cases and controls, and the association with clinicopathological parameters among cases was studied.
resultsThe frequency of 1G/2G genotypes in gastric cancer patients was similar to those in controls (p=0.57). The degree of tumor invasion, the presence of lymph node metastasis, and clinical stage showed no significant association with the SNP. On the other hand, we found a significant association with histological differentiation and gender among gastric cancer patients (p<0.05, respectively).
conclusionsThe presence of 2G allele in the MMP-1 promoter did not enhance the risk of gastric cancer; however, it may be involved in differentiation of gastric cancer.
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