ReviewGene therapy2004
Gene therapy progress and prospects: transcription regulatory systems.
Review in Gene therapy, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 133 citations in OpenAlex.
- Synthetic dynamic transcription frameworks and their applications.Nature chemistry · 2026Review
- Advances in hydrogel-mediated gene therapy in ophthalmology: future directions and therapeutic potential.Regenerative biomaterials · 2026Review
- Ligand-induced assembly of antibody variable fragments for the chemical regulation of biological processes.Cell chemical biology · 2025Article
- Lentiviral vectors for inducible, transactivator-free advanced therapy medicinal products: Application to CAR-T cells.Molecular therapy. Nucleic acids · 2023Article
- Autoinhibited transient, gated, and cascaded dynamic transcription of RNAs.Science advances · 2022Article
- Pulsed Electric Fields Alter Expression of NF-κB Promoter-Controlled Gene.International journal of molecular sciences · 2021Article
- Cochlear Gene Therapy.Cold Spring Harbor perspectives in medicine · 2019Review
- Improving miRNA Delivery by Optimizing miRNA Expression Cassettes in Diverse Virus Vectors.Human gene therapy methods · 2017Review
- Single vector non-leaky gene expression system for Drosophila melanogaster.Scientific reports · 2017Article
- An Autogenously Regulated Expression System for Gene Therapeutic Ocular Applications.Scientific reports · 2015Article
- Riboswitch-mediated Attenuation of Transgene Cytotoxicity Increases Adeno-associated Virus Vector Yields in HEK-293 Cells.Molecular therapy : the journal of the American Society of Gene Therapy · 2015Article
- Applying an Inducible Expression System to Study Interference of Bacterial Virulence Factors with Intracellular Signaling.Journal of visualized experiments : JoVE · 2015Article
- Establishment of a cellular model to study TrkC-dependent neuritogenesis.In vitro cellular & developmental biology. Animal · 2015Article
- Cellular immunotherapy for pediatric solid tumors.Cytotherapy · 2015Review
- Viral expression cassette elements to enhance transgene target specificity and expression in gene therapy.Discovery medicine · 2015Review
- Optical control of retrogradely infected neurons using drug-regulated "TLoop" lentiviral vectors.Journal of neurophysiology · 2014Article
- Artificial riboswitches for gene expression and replication control of DNA and RNA viruses.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Article
- Design and implementation of adoptive therapy with chimeric antigen receptor-modified T cells.Immunological reviews · 2014Review
- A next step in adeno-associated virus-mediated gene therapy for neurological diseases: regulation and targeting.British journal of clinical pharmacology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The clinical efficacy and safety as well as the application range of gene therapy will be broadened by developing systems capable of finely modulating the expression of therapeutic genes. Transgene regulation will be crucial for maintaining appropriate levels of a gene product within the therapeutic range, thus preventing toxicity. Moreover, the possibility to modulate, stop or resume transgene expression in response to disease evolution would facilitate the combination of gene therapy with more conventional therapeutic modalities. The development of ligand-dependent transcription regulatory systems is thus of great importance. Here, we summarize the most recent progress in the field.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.