ReviewJournal of mammary gland biology and neoplasia2003
Eph and ephrin signaling in mammary gland morphogenesis and cancer.
Review in Journal of mammary gland biology and neoplasia, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 36 citations in OpenAlex.
- Loss of EphA7 Expression in Basal Cell Carcinoma by Hypermethylation of CpG Islands in the Promoter Region.Analytical cellular pathology (Amsterdam) · 2022Article
- Regulatory roles of ephrinA5 and its novel signaling pathway in mouse primary granulosa cell apoptosis and proliferation.Cell cycle (Georgetown, Tex.) · 2018Article
- Epha3 acts as proangiogenic factor in multiple myeloma.Oncotarget · 2017Article
- EPH/ephrin profile and EPHB2 expression predicts patient survival in breast cancer.Oncotarget · 2016Article
- Expression of Eph A4, Eph B2 and Eph B4 receptors in AML.Pathology oncology research : POR · 2014Article
- Roles of EphA2 in Development and Disease.Genes · 2013Article
- Age-associated gene expression in normal breast tissue mirrors qualitative age-at-incidence patterns for breast cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2012Article
- EphB4 is overexpressed in papillary thyroid carcinoma and promotes the migration of papillary thyroid cancer cells.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2012Article
- Emerging strategies for EphA2 receptor targeting for cancer therapeutics.Expert opinion on therapeutic targets · 2011Review
- The mammary gland vasculature revisited.Journal of mammary gland biology and neoplasia · 2010Review
- Regulation of mammary gland branching morphogenesis by EphA2 receptor tyrosine kinase.Molecular biology of the cell · 2009Article
- A subset of signal transduction pathways is required for hippocampal growth cone collapse induced by ephrin-A5.Developmental neurobiology · 2008Article
- Pubertal mammary gland development: insights from mouse models.Journal of mammary gland biology and neoplasia · 2006Review
- Eph and ephrins in epithelial stem cell niches and cancer.Cell adhesion & migrationReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Eph family of receptor tyrosine kinases and their membrane-bound ligands, the ephrins, play a central role in pattern formation during embryonic development and there is growing evidence that they are also instrumental in the control of tissue dynamics in the adult. The mammary gland is a paradigm for morphogenic processes occurring in the adult, since the gland develops predominantly postnatally and is subjected to continuous cyclic remodeling according to functional demands. Thus, pattern formation and the establishment of a functional organ structure are permanent themes in the mammary gland life cycle. In this paper we summarize the experimental evidence and discuss possible mechanisms by which Ephs and ephrins are modulating mammary epithelial cell adhesion, communication, and migration. Furthermore, we speculate on the different aspects of their influence on normal mammary gland development, function, and carcinogenesis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.