ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
A pro-apoptotic fragment of the p75 neurotrophin receptor is expressed in p75NTRExonIV null mice.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 77 citations in OpenAlex.
- p75 neurotrophin receptor shapes the dynamics of adult hippocampal neurogenesis in Alzheimer's disease.Alzheimer's research & therapy · 2026Article
- Redundancy of p75NTR neurotrophin receptor function in development, growth and fertility in the rat.Transgenic research · 2024Article
- Deletion of p75Frontiers in molecular neuroscience · 2023Article
- Sexual Dimorphism in Balance and Coordination in p75NTRFrontiers in behavioral neuroscience · 2022Article
- Brain-derived neurotrophic factor precursor in the immune system is a novel target for treating multiple sclerosis.Theranostics · 2021Article
- Saikosaponin-d impedes hippocampal neurogenesis and causes cognitive deficits by inhibiting the survival of neural stem/progenitor cells via neurotrophin receptor signaling in mice.Clinical and translational medicine · 2020Article
- Peripheral Nerve Regeneration Is Independent From Schwann Cell p75Frontiers in cellular neuroscience · 2019Article
- Regulation of Neurogenesis by Neurotrophins during Adulthood: Expected and Unexpected Roles.Frontiers in neuroscience · 2016Review
- L-type Calcium Channel Cav1.2 Is Required for Maintenance of Auditory Brainstem Nuclei.The Journal of biological chemistry · 2015Article
- The role of p75NTR in cholinergic basal forebrain structure and function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Glycyrrhizin improves p75NTR-associated sciatic nerve regeneration in a BALB/c mouse model.Experimental and therapeutic medicine · 2014Article
- Nerve growth factor-induced cell cycle reentry in newborn neurons is triggered by p38MAPK-dependent E2F4 phosphorylation.Molecular and cellular biology · 2012Article
- Article
- Generation of mice with a conditional allele for the p75(NTR) neurotrophin receptor gene.Genesis (New York, N.Y. : 2000) · 2011Article
- Axotomy-induced neurotrophic withdrawal causes the loss of phenotypic differentiation and downregulation of NGF signalling, but not death of septal cholinergic neurons.Molecular neurodegeneration · 2010Article
- NTRK1 and NTRK2 receptors facilitate follicle assembly and early follicular development in the mouse ovary.Reproduction (Cambridge, England) · 2009Article
- Cardiovascular actions of neurotrophins.Physiological reviews · 2009Review
- Role of neurotrophic factors in early ovarian development.Seminars in reproductive medicine · 2009Review
- Gamma-secretase represents a therapeutic target for the treatment of invasive glioma mediated by the p75 neurotrophin receptor.PLoS biology · 2008Article
- Chronically increased ciliary neurotrophic factor and fibroblast growth factor-2 expression after spinal contusion in rats.The Journal of comparative neurology · 2008Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The p75 neurotrophin receptor (p75NTR) regulates neuronal survival, apoptosis, and growth. Recent studies have reported that disruption of Exon IV produces a null mouse lacking all p75NTR gene products (p75NTRExonIV-/-), whereas mice lacking p75NTR Exon III (p75NTRExonIII-/-) maintain expression of an alternatively spliced form of p75NTR (s-p75NTR). Here, we report that p75NTRExonIV-/- mice express a p75NTR gene product that encodes a truncated protein containing the extracellular stalk region together with the entire transmembrane and intracellular domains. The gene product is initiated from a cryptic Kozak consensus/initiator ATG sequence within a region of Exon IV located 3' to the pGK-Neo insertion site. Overexpression of this fragment in heterologous cells results in activation of Jun kinase and induces Pro-caspase-3 cleavage, indicating that it activates p75NTR signaling cascades. These results indicate that aspects of the p75NTRExonIV-/- phenotype may reflect a gain-of-function mutation rather than loss of p75NTR function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.