ArticleChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2004
Applications of combined DNA microarray and chromosome sorting technologies.
Article in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 103 citations in OpenAlex.
- Characterising chromosome rearrangements: recent technical advances in molecular cytogenetics.Heredity · 2012Review
- Array painting: a protocol for the rapid analysis of aberrant chromosomes using DNA microarrays.Nature protocols · 2009Article
- Clinical implementation of chromosomal microarray analysis: summary of 2513 postnatal cases.PloS one · 2007Article
- A high-resolution map of synteny disruptions in gibbon and human genomes.PLoS genetics · 2006Article
- Application of array CGH on archival formalin-fixed paraffin-embedded tissues including small numbers of microdissected cells.Laboratory investigation; a journal of technical methods and pathology · 2006Article
- Mouse chromosome engineering for modeling human disease.Annual review of genomics and human genetics · 2006Review
- Article
- Multicolor chromosome painting in diagnostic and research applications.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2004Review
- Chromosome paints from single copies of chromosomes.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2004Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The sequencing of the human genome has led to the availability of an extensive mapped clone resource that is ideal for the construction of DNA microarrays. These genomic clone microarrays have largely been used for comparative genomic hybridisation studies of tumours to enable accurate measurement of copy number changes (array-CGH) at increased resolution. We have utilised these microarrays as the target for chromosome painting and reverse chromosome painting to provide a similar improvement in analysis resolution for these studies in a process we have termed array painting. In array painting, chromosomes are flow sorted, fluorescently labelled and hybridised to the microarray. The complete composition and the breakpoints of aberrant chromosomes can be analysed at high resolution in this way with a considerable reduction in time, effort and cytogenetic expertise required for conventional analysis using fluorescence in situ hybridisation. In a similar way, the resolution of cross-species chromosome painting can be improved and we present preliminary observations of the organisation of homologous DNA blocks between the white cheeked gibbon chromosome 14 and human chromosomes 2 and 17.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.