Evidence map›Paper›PMID 14984098›Full record

ReviewChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2004

Multicolor chromosome painting in diagnostic and research applications.

Sabine Langer, Jürgen Kraus, Isabell Jentsch, Michael R Speicher

Abstract readReview
PubMed Publisher
In one paragraph

Review in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Chromosomes in the flow to simplify genome analysis.Functional & integrative genomics · 2012
    Review
  3. Genome-scale approaches to investigate oxidative DNA damage.Journal of clinical biochemistry and nutrition · 2010
    Article
  4. Canine cytogenetics--from band to basepair.Cytogenetic and genome research · 2008
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Generation of chromosome painting probes from single chromosomes by laser microdissection and linker-adaptor PCR.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2004
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sabine LangerInstitut für Humangenetik, Technische Universität München, Trogerstr. 32, D-81675 München, Germany.
Jürgen Kraus
Isabell Jentsch
Michael R Speicher

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

For many years whole chromosome painting probes have been the work-horses in a large variety of clinical and research molecular cytogenetic applications. In recent years painting probes have been complemented by an increasing number of further region-specific probes, which allow the specific staining of centromeres, subtelomeres or other regions within the genome. This development of new probe sets was greatly facilitated by the Human Genome Project from which well-characterized probes for any region within the genome have emerged. Furthermore, the evolution of different multicolor fluorescence in situ hybridization (FISH) technologies now allows the cohybridization of multiple DNA-probes of different colors. These developments have paved the way for FISH-based automated karyotyping or the simultaneous analysis of multiple defined regions within the genome. Using appropriate instrumentation and image processing, the analysis can be performed two-dimensionally on metaphase spreads or three-dimensionally in intact interphase nuclei. Here we summarize some of the most recent developments and discuss the application of painting probes in different scenarios.

Indexed as

Research DesignAnimalsChromosome PaintingDNA ProbesFemaleHumansInterphaseKaryotypingMetaphaseMiceDNA Probes

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.