ArticleCell stress & chaperones2003
Stress to cadmium monitored by metallothionein gene induction in Paracentrotus lividus embryos.
Article in Cell stress & chaperones, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 73 citations in OpenAlex.
- Remodeling of Embryo Architecture in Response to Vanadium and Increased Temperatures: From Morphometric to Molecular Changes.Journal of xenobiotics · 2025Article
- Between Life and Death: Sea Urchin Embryos Undergo Peculiar DNA Fragmentation after Exposure to Vanadium, Cadmium, Gadolinium, and Selenium.Life (Basel, Switzerland) · 2024Article
- Vanadium Modulates Proteolytic Activities and MMP-14-Like Levels duringInternational journal of molecular sciences · 2022Article
- Cadmium stress effects indicating marine pollution in different species of sea urchin employed as environmental bioindicators.Cell stress & chaperones · 2019Review
- Metallothionein Gene Family in the Sea Urchin Paracentrotus lividus: Gene Structure, Differential Expression and Phylogenetic Analysis.International journal of molecular sciences · 2017Article
- New insights into negative effects of lithium on sea urchin Paracentrotus lividus embryos.Scientific reports · 2016Article
- Autophagy as a defense strategy against stress: focus on Paracentrotus lividus sea urchin embryos exposed to cadmium.Cell stress & chaperones · 2016Review
- Titanium dioxide nanoparticles stimulate sea urchin immune cell phagocytic activity involving TLR/p38 MAPK-mediated signalling pathway.Scientific reports · 2015Article
- Maternal Exposure to Cadmium and Manganese Impairs Reproduction and Progeny Fitness in the Sea Urchin Paracentrotus lividus.PloS one · 2015Article
- Differential expression of metallothionein isoforms in terrestrial snail embryos reflects early life stage adaptation to metal stress.PloS one · 2015Article
- Molecular response to toxic diatom-derived aldehydes in the sea urchin Paracentrotus lividus.Marine drugs · 2014Article
- Effects of cadmium exposure on sea urchin development assessed by SSH and RT-qPCR: metallothionein genes and their differential induction.Molecular biology reports · 2013Article
- Article
- Stress response induced by carbon nanoparticles in Paracentrotus lividus.International journal of molecular and cellular medicine · 2012Article
- Article
- Rapid changes in heat-shock cognate 70 levels, heat-shock cognate phosphorylation state, heat-shock transcription factor, and metal transcription factor activity levels in response to heavy metal exposure during sea urchin embryonic development.Ecotoxicology (London, England) · 2011Article
- Transcriptional increase and misexpression of 14-3-3 epsilon in sea urchin embryos exposed to UV-B.Cell stress & chaperones · 2010Article
- Embryonic development and skeletogenic gene expression affected by X-rays in the Mediterranean sea urchin Paracentrotus lividus.Ecotoxicology (London, England) · 2010Article
- Sea urchin embryos as an in vivo model for the assessment of manganese toxicity: developmental and stress response effects.Ecotoxicology (London, England) · 2010Article
- Cadmium induces an apoptotic response in sea urchin embryos.Cell stress & chaperones · 2007Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We used sea urchin embryos as bioindicators to study the effects of exposure to sublethal cadmium concentrations on the expression of the metallothionein (MT) gene stress marker. For this purpose, the complete complementary deoxyribonucleic acid of the species Paracentrotus lividus (Pl) was cloned and sequenced. Northern blot analysis showed that basal levels of Pl-MT messenger ribonucleic acid, having an apparent size of 700 bases, are expressed in all developmental stages analyzed, from early cleavage to pluteus. However, when embryos were continuously cultured in sublethal CdCl2 concentrations and harvested at cleavage, swimming blastula, late gastrula, and pluteus stages (6, 12, 24, and 48 hours after fertilization, respectively), a time- and dose-dependent increase in the transcription levels of the Pl-MT gene was observed. Interestingly, although microscopical inspection revealed the occurrence of abnormalities only after 24 hours of exposure to the pollutant, Northern blot and reverse transcriptase-polymerase chain reaction analyses revealed significant increases in Pl-MT expression levels already after 12 and 6 hours of exposure, respectively. Therefore, this study confirms the validity of MT as marker of exposure and provides evidence that Pl-MT and sea urchin embryos can be a potentially valuable and sensitive model for testing in very short periods of time seawaters heavily contaminated with cadmium.
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