ArticleProceedings of the National Academy of Sciences of the United States of America2004
Negative regulation of IFN-alpha/beta signaling by IFN regulatory factor 2 for homeostatic development of dendritic cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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Who cites it
37 citing papers in PubMed, 98 citations in OpenAlex.
- Intrathymic Regulation of Dendritic Cell Subsets and Their Contributions to Central Tolerance.Immunological reviews · 2025Review
- The IRF2-INPP4B Pathway Aggravates Acute Myeloid LeukemiaTurkish journal of haematology : official journal of Turkish Society of Haematology · 2025Article
- Genomic analysis of progenitors in viral infection implicates glucocorticoids as suppressors of plasmacytoid dendritic cell generation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Role and mechanism of gut microbiota in regulating interferon-mediated programmed cell death in colorectal cancer.Frontiers in immunology · 2025Review
- Genome-wide screening identifies Trim33 as an essential regulator of dendritic cell differentiation.Science immunology · 2024Article
- Ablation of Adar1 in myeloid cells imprints a global antiviral state in the lung and heightens early immunity against SARS-CoV-2.Cell reports · 2023Article
- NKL Homeobox Gene VENTX Is Part of a Regulatory Network in Human Conventional Dendritic Cells.International journal of molecular sciences · 2021Article
- Article
- Identification of Interleukin1β as an Amplifier of Interferon alpha-induced Antiviral Responses.PLoS pathogens · 2020Article
- Regulating IRFs in IFN Driven Disease.Frontiers in immunology · 2019Review
- The Molecular Basis of Viral Inhibition of IRF- and STAT-Dependent Immune Responses.Frontiers in immunology · 2018Review
- Interferon regulatory factor 2 protects mice from lethal viral neuroinvasion.The Journal of experimental medicine · 2016Article
- Type I IFN promotes NK cell expansion during viral infection by protecting NK cells against fratricide.The Journal of experimental medicine · 2016Article
- The Essential Role of Type I Interferons in Differentiation and Activation of Tumor-Associated Neutrophils.Frontiers in immunology · 2016Review
- TRIM13 is a negative regulator of MDA5-mediated type I interferon production.Journal of virology · 2014Article
- Batf3 and Id2 have a synergistic effect on Irf8-directed classical CD8α+ dendritic cell development.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Dendritic cell development: a choose-your-own-adventure story.Advances in hematology · 2013Article
- Regulation of T helper cell differentiation by interferon regulatory factor family members.Immunologic research · 2012Review
- Conditional IFNAR1 ablation reveals distinct requirements of Type I IFN signaling for NK cell maturation and tumor surveillance.Oncoimmunology · 2012Article
- A STATus report on DC development.Journal of leukocyte biology · 2012Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development and cooperation of distinct subsets of antigen-presenting cells, particularly dendritic cells (DCs), may be critical for maintaining homeostatic immune responses. Recently, much attention has been focused on IFN-alpha/beta, the cytokines induced en masse by virus infection or the activation of Toll-like receptors, in the context of DC activation. Here, we show that mice deficient in IFN regulatory factor 2 exhibit selective loss of CD8alpha- DCs, the so-called myeloid DCs, which is accompanied by a notable increase in CD11c-CD11bhigh other myeloid lineage cells. Such deficiency is intrinsic to the bone marrow precursors, in which the abnormal induction of IFN-alpha/beta genes causes excessive IFN signaling. The critical function of IFN regulatory factor 2 in the negative regulation of IFN-alpha/beta signaling is underscored by the observation that the deficiency is rescued by introducing an additional null mutation for the IFN receptor complex. In view of accumulating evidence of the critical role of IFN-alpha/beta signaling in DC activation, our present study offers a unique example in that the magnitude of a cytokine signal should be properly balanced in a stage-specific manner during the differentiation and activation of DCs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.