ArticleProceedings of the National Academy of Sciences of the United States of America2004
Exceptional conservation of horse-human gene order on X chromosome revealed by high-resolution radiation hybrid mapping.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 68 citations in OpenAlex.
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- Hi-C scaffolded short- and long-read genome assemblies of the California sea lion are broadly consistent for syntenic inference across 45 million years of evolution.Molecular ecology resources · 2021Article
- Genomic architecture constrained placental mammal X Chromosome evolution.Genome research · 2021Article
- Molecular Composition of Heterochromatin and Its Contribution to Chromosome Variation in theGenes · 2021Article
- The X chromosome and male infertility.Human genetics · 2021Review
- Generation of a Biobank From Two Adult Thoroughbred Stallions for the Functional Annotation of Animal Genomes Initiative.Frontiers in genetics · 2021Article
- X-Linked Signature of Reproductive Isolation in Humans is Mirrored in a Howler Monkey Hybrid Zone.The Journal of heredity · 2020Article
- Recombination-Aware Phylogenomics Reveals the Structured Genomic Landscape of Hybridizing Cat Species.Molecular biology and evolution · 2019Article
- Alignment-free method for DNA sequence clustering using Fuzzy integral similarity.Scientific reports · 2019Article
- Generation of an equine biobank to be used for Functional Annotation of Animal Genomes project.Animal genetics · 2018Article
- X Chromosome Evolution in Cetartiodactyla.Genes · 2017Article
- Y chromosome palindromes and gene conversion.Human genetics · 2017Review
- Deficit of mitonuclear genes on the human X chromosome predates sex chromosome formation.Genome biology and evolution · 2015Article
- Independent specialization of the human and mouse X chromosomes for the male germ line.Nature genetics · 2013Article
- Acceleration of X-chromosome gene order evolution in the cattle lineage.BMB reports · 2013Article
- Rapid divergence and expansion of the X chromosome in papaya.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Evolutionary history of novel genes on the tammar wallaby Y chromosome: Implications for sex chromosome evolution.Genome research · 2012Article
- A cross-species comparison of escape from X inactivation in Eutheria: implications for evolution of X chromosome inactivation.Chromosoma · 2012Article
- Genome sequence of an Australian kangaroo, Macropus eugenii, provides insight into the evolution of mammalian reproduction and development.Genome biology · 2011Article
- A large expansion of the HSFY gene family in cattle shows dispersion across Yq and testis-specific expression.PloS one · 2011Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Development of a dense map of the horse genome is key to efforts aimed at identifying genes controlling health, reproduction, and performance. We herein report a high-resolution gene map of the horse (Equus caballus) X chromosome (ECAX) generated by developing and typing 116 gene-specific and 12 short tandem repeat markers on the 5,000-rad horse x hamster whole-genome radiation hybrid panel and mapping 29 gene loci by fluorescence in situ hybridization. The human X chromosome sequence was used as a template to select genes at 1-Mb intervals to develop equine orthologs. Coupled with our previous data, the new map comprises a total of 175 markers (139 genes and 36 short tandem repeats, of which 53 are fluorescence in situ hybridization mapped) distributed on average at approximately 880-kb intervals along the chromosome. This is the densest and most uniformly distributed chromosomal map presently available in any mammalian species other than humans and rodents. Comparison of the horse and human X chromosome maps shows remarkable conservation of gene order along the entire span of the chromosomes, including the location of the centromere. An overview of the status of the horse map in relation to mouse, livestock, and companion animal species is also provided. The map will be instrumental for analysis of X linked health and fertility traits in horses by facilitating identification of targeted chromosomal regions for isolation of polymorphic markers, building bacterial artificial chromosome contigs, or sequencing.
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