ArticleThe American journal of pathology2004
Human pancreatic islet-derived progenitor cell engraftment in immunocompetent mice.
Article in The American journal of pathology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 48 citations in OpenAlex.
- The Dark Side of the Force - Constraints and Complications of Cell Therapies for Stroke.Frontiers in neurology · 2015Review
- Mesenchymal stem cells as a novel vaccine platform.Frontiers in cellular and infection microbiology · 2012Article
- Article
- Xenotransplantation of embryonic pig kidney or pancreas to replace the function of mature organs.Journal of transplantation · 2011Article
- Engraftment of insulin-producing cells from porcine islets in non-immune-suppressed rats or nonhuman primates transplanted previously with embryonic pig pancreas.Journal of transplantation · 2011Article
- Identification of a novel putative pancreatic stem/progenitor cell marker DCAMKL-1 in normal mouse pancreas.American journal of physiology. Gastrointestinal and liver physiology · 2010Article
- Engraftment of cells from porcine islets of Langerhans and normalization of glucose tolerance following transplantation of pig pancreatic primordia in nonimmune-suppressed diabetic rats.The American journal of pathology · 2010Article
- Human islet-derived precursor cells can cycle between epithelial clusters and mesenchymal phenotypes.Journal of cellular and molecular medicine · 2009Article
- Xenotransplantation of pancreatic and kidney primordia-where do we stand?Transplant immunology · 2009Article
- Article
- Normalization of glucose post-transplantation into diabetic rats of pig pancreatic primordia preserved in vitro.Organogenesis · 2008Article
- Organogenesis of kidney and endocrine pancreas: the window opens.Organogenesis · 2007Article
- Nestin expression in pancreatic endocrine and exocrine cells of mice lacking glucagon signaling.Developmental dynamics : an official publication of the American Association of Anatomists · 2007Article
- Article
- Gene therapy progress and prospects: gene therapy for diabetes mellitus.Gene therapy · 2005Review
- Article
- Organogenetic tolerance.OrganogenesisReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The potential for the use of stem/progenitor cells for the restoration of injured or diseased tissues has garnered much interest recently, establishing a new field of research called regenerative medicine. Attention has been focused on embryonic stem cells derived from human fetal tissues. However, the use of human fetal tissue for research and transplantation is controversial. An alternative is the isolation and utilization of multipotent stem/progenitor cells derived from adult donor tissues. We have previously reported on the isolation, propagation, and partial characterization of a population of stem/progenitor cells isolated from the pancreatic islets of Langerhans of adult human donor pancreata. Here we show that these human adult tissue-derived cells, nestin-positive islet-derived stem/progenitor cells, prepared from human adult pancreata survive engraftment and produce tissue chimerism when transplanted into immunocompetent mice either under the kidney capsule or by systemic injection. These xenografts seem to induce immune tolerance by establishing a mixed chimerism in the mice. We propose that a population of stem/progenitor cells isolated from the islets of the pancreas can cross xenogeneic transplantation immune barriers, induce tissue tolerance, and grow.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.