ArticleOncogene2004
Autocrine stimulation by osteopontin plays a pivotal role in the expression of the mitogenic and invasive phenotype of RET/PTC-transformed thyroid cells.
Article in Oncogene, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 46 citations in OpenAlex.
- Deletion of p18Stem cell research & therapy · 2025Article
- The Intracellular and Secreted Sides of Osteopontin and Their Putative Physiopathological Roles.International journal of molecular sciences · 2023Review
- Osteopontin Expression in Thyroid Cancer: Deciphering EMT-Related Molecular Mechanisms.Biomedicines · 2021Review
- OPNa Overexpression Is Associated with Matrix Calcification in Thyroid Cancer Cell Lines.International journal of molecular sciences · 2018Article
- Characteristics of a thyroid carcinoma cell line derived from spinal metastasis.Bioscience reports · 2016Article
- Interleukins as markers of inflammation in malignant and benign thyroid disease.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2014Article
- Osteopontin expression in papillary thyroid carcinoma and its relationship with the BRAF mutation and tumor characteristics.Journal of the Korean Surgical Society · 2013Article
- Inflammation in thyroid oncogenesis.American journal of cancer research · 2012Article
- Osteopontin: an effector and an effect of tumor metastasis.Current molecular medicine · 2010Review
- RET/PTC1-driven neoplastic transformation and proinvasive phenotype of human thyrocytes involve Met induction and beta-catenin nuclear translocation.Neoplasia (New York, N.Y.) · 2009Article
- Gene expression profiling of papillary thyroid carcinoma identifies transcripts correlated with BRAF mutational status and lymph node metastasis.Clinical cancer research : an official journal of the American Association for Cancer Research · 2008Article
- Expression microarray analysis of papillary thyroid carcinoma and benign thyroid tissue: emphasis on the follicular variant and potential markers of malignancy.Virchows Archiv : an international journal of pathology · 2007Article
- Article
- Induction of a proinflammatory program in normal human thyrocytes by the RET/PTC1 oncogene.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells.The Journal of clinical investigation · 2005Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Papillary thyroid carcinomas are characterized by rearrangements of the RET receptor tyrosine kinase generating RET/PTC oncogenes. Here we show that osteopontin (OPN), a secreted glycoprotein, is a major RET/PTC-induced transcriptional target in PC Cl 3 thyroid follicular cells. OPN upregulation depended on the integrity of the RET/PTC kinase and tyrosines Y1015 and Y1062, two major RET/PTC autophosphorylation sites. RET/PTC also induced a strong overexpression of CD44, a cell surface signalling receptor for OPN. Upregulation of CD44 was dependent on RET/PTC Y1062, as well. Constitutive OPN overexpression or treatment with exogenous recombinant OPN sharply increased proliferation, Matrigel invasion and spreading in collagen gels of RET/PTC-transformed PC Cl 3 cells. These effects were impaired by the treatment of PC Cl 3-RET/PTC cells with OPN- and CD44-locking antibodies. Thus, RET/PTC signalling triggers an autocrine loop involving OPN and CD44 that sustains proliferation and invasion of transfomed PC Cl 3 thyrocytes.
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