ArticleMolecular psychiatry2004
A functional polymorphism in the succinate-semialdehyde dehydrogenase (aldehyde dehydrogenase 5 family, member A1) gene is associated with cognitive ability.
Article in Molecular psychiatry, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Determination of system level alterations in host transcriptome due to Zika virus (ZIKV) Infection in retinal pigment epithelium.Scientific reports · 2018Pooled it
- Altered gene expression in early postnatal monoamine oxidase A knockout mice.Brain research · 2017Article
- Succinic semialdehyde dehydrogenase deficiency (SSADHD): Pathophysiological complexity and multifactorial trait associations in a rare monogenic disorder of GABA metabolism.Neurochemistry international · 2016Review
- The DYX2 locus and neurochemical signaling genes contribute to speech sound disorder and related neurocognitive domains.Genes, brain, and behavior · 2015Article
- Characterization of the DYX2 locus on chromosome 6p22 with reading disability, language impairment, and IQ.Human genetics · 2014Article
- Schooling and variation in the COMT gene: the devil is in the details.Journal of child psychology and psychiatry, and allied disciplines · 2013Article
- Why it is hard to find genes associated with social science traits: theoretical and empirical considerations.American journal of public health · 2013Article
- The Promises and Pitfalls of Genoeconomics*Annual review of economics · 2012Article
- Gene-based analysis of regionally enriched cortical genes in GWAS data sets of cognitive traits and psychiatric disorders.PloS one · 2012Article
- Most reported genetic associations with general intelligence are probably false positives.Psychological science · 2012Article
- The ATXN1 and TRIM31 genes are related to intelligence in an ADHD background: evidence from a large collaborative study totaling 4,963 subjects.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2011Article
- Evolutionary genomics of human intellectual disability.Evolutionary applications · 2010Article
- The impact of genetic research on our understanding of normal cognitive ageing: 1995 to 2009.Neuropsychology review · 2009Review
- Genetic foundations of human intelligence.Human genetics · 2009Review
- Comparative genomics of aldehyde dehydrogenase 5a1 (succinate semialdehyde dehydrogenase) and accumulation of gamma-hydroxybutyrate associated with its deficiency.Human genomics · 2009Review
- Exploring the functional role of the CHRM2 gene in human cognition: results from a dense genotyping and brain expression study.BMC medical genetics · 2007Article
- The emergence of genomic psychology. Insights from genomic analyses might allow psychologists to understand, predict and modify human behaviour.EMBO reports · 2007Review
- SSADH variation in primates: intra- and interspecific data on a gene with a potential role in human cognitive functions.Journal of molecular evolution · 2006Article
- A genomewide scan for intelligence identifies quantitative trait loci on 2q and 6p.American journal of human genetics · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Succinate-semialdehyde dehydrogenase (SSADH) deficiency is a rare cause of learning disability. We have investigated SSADH to assess its contribution to cognitive ability in the general population in both case-control- and family-based analyses. Sequence analysis of SSADH revealed four changes affecting the encoded protein, only one of which had a minor allele whose frequency is even moderately common. We genotyped this functional polymorphism in 197 high-IQ cases, 201 average-IQ controls and 196 parent high-IQ offspring trios. The minor allele was significantly less frequent in high-IQ cases and was significantly less frequently transmitted by parents to high-IQ subjects than chance expectation. A previous study has shown that the minor allele encodes a lower activity enzyme than the major allele. These data suggest that higher SSADH activity is associated with higher intelligence across the general population. The effect is small, with each allele having an effect size translating to about 1.5 IQ points.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.