ArticleProceedings of the National Academy of Sciences of the United States of America2004
Intrachromosomal excision of a hybrid Ds element induces large genomic deletions in Arabidopsis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed.
- Toward the development of Ac/Ds transposon-mediated gene tagging system for functional genomics in oat (Avena sativa L.).Functional & integrative genomics · 2022Article
- Suicidal autointegration of sleeping beauty and piggyBac transposons in eukaryotic cells.PLoS genetics · 2014Article
- The PSBP2 protein of Chlamydomonas reinhardtii is required for singlet oxygen-dependent signaling.Planta · 2012Article
- Genome rearrangements in maize induced by alternative transposition of reversed ac/ds termini.Genetics · 2011Article
- Genome-wide distribution of transposed Dissociation elements in maize.The Plant cell · 2010Article
- A collection of Ds insertional mutants associated with defects in male gametophyte development and function in Arabidopsis thaliana.Genetics · 2009Article
- Alternative Ac/Ds transposition induces major chromosomal rearrangements in maize.Genes & development · 2009Article
- Reversed end Ds element: a novel tool for chromosome engineering in Arabidopsis.Plant molecular biology · 2008Article
- Macrotransposition and other complex chromosomal restructuring in maize by closely linked transposons in direct orientation.The Plant cell · 2008Article
- Transposon excision from an atypical site: a mechanism of evolution of novel transposable elements.PloS one · 2007Article
- Transposable elements in fish functional genomics: technical challenges and perspectives.Genome biology · 2007Review
- Transposition of reversed Ac element ends generates novel chimeric genes in maize.PLoS genetics · 2006Article
- Targeted Ds-tagging strategy generates high allelic diversity at the Arabidopsis HY2 locus.Plant molecular biology · 2006Article
- The RPN1 subunit of the 26S proteasome in Arabidopsis is essential for embryogenesis.The Plant cell · 2005Article
- A segmental deletion series generated by sister-chromatid transposition of Ac transposable elements in maize.Genetics · 2005Article
- Mitotic instability in wheat x Thinopyrum ponticum derivatives revealed by chromosome counting, nuclear DNA content and histone H3 phosphorylation pattern.Plant cell reports · 2005Article
- The Oryza sativa no pollen (Osnop) gene plays a role in male gametophyte development and most likely encodes a C2-GRAM domain-containing protein.Plant molecular biology · 2005Article
- Characterization of an unusual Ds transposable element in Arabidopsis thaliana: insertion of an abortive circular transposition intermediate.Plant molecular biology · 2004Article
- Transposition of reversed Ac element ends generates chromosome rearrangements in maize.Genetics · 2004Article
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6 authors.
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Abstract
Transposon activity is known to cause chromosome rearrangements in the host genome. Surprisingly, extremely little is known about Dissociation (Ds)-induced chromosome rearrangements in Arabidopsis, where Ds is intensively used for insertional mutagenesis. Here, we describe three Arabidopsis mutants with reduced fertility and propose that excision of a hybrid Ds element induced a large genomic deletion flanking Ds. In the mutants anat and haumea, the deletion mechanism consists of a local Ds transposition from replicated into unreplicated DNA followed by Ds excision, where one end of the newly transposed element and one end of the Ds transposon at the donor site served as substrate for transposase. Excision of this hybrid element reminiscent of a macrotransposon leads to loss of the chromosomal piece located between the two ends, including one full Ds element and the flanking genomic sequence. This mechanism was found to be responsible for several other deletions and occurs at a genetically trackable frequency. Thus, it could be applied to efficiently generate deletions of various sizes in the vicinity of any existing Ds element present in the genome. In the mutant tons missing, a mechanism that involves endogenous repetitive sequences caused a large flanking deletion at a position unlinked to the starter locus. Our study of Ds transposition in Arabidopsis revealed previously undescribed mechanisms that lead to large genomic deletions flanking Ds elements, which may contribute to genome dynamics and evolution.
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