ArticleThe Journal of cell biology2004
Epiblast cells that express MyoD recruit pluripotent cells to the skeletal muscle lineage.
Article in The Journal of cell biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed.
- MyoD is required for the differentiation of Myo/Nog cell progenitors of myofibroblasts in explants of human lens tissue.Frontiers in ophthalmology · 2025Article
- Review
- Myo/Nog Cells Give Rise to Myofibroblasts During Epiretinal Membrane Formation in a Mouse Model of Proliferative Vitreoretinopathy.Investigative ophthalmology & visual science · 2023Article
- Acute Response and Neuroprotective Role of Myo/Nog Cells Assessed in a Rat Model of Focal Brain Injury.Frontiers in neuroscience · 2021Article
- Fgf-driven Tbx protein activities directly induceDevelopment (Cambridge, England) · 2020Article
- Myo/Nog cells are nonprofessional phagocytes.PloS one · 2020Article
- Article
- Article
- Myo/Nog cells: targets for preventing the accumulation of skeletal muscle-like cells in the human lens.PloS one · 2014Article
- Myo/Nog cell regulation of bone morphogenetic protein signaling in the blastocyst is essential for normal morphogenesis and striated muscle lineage specification.Developmental biology · 2011Article
- Emerging roles for the transforming growth factor-{beta} superfamily in regulating adiposity and energy expenditure.Endocrine reviews · 2011Review
- Unique precursors for the mesenchymal cells involved in injury response and fibrosis.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Noggin producing, MyoD-positive cells are crucial for eye development.Developmental biology · 2009Article
- Tracking and ablating subpopulations of epiblast cells in the chick embryo.Biological procedures online · 2008Article
- Cells that express MyoD mRNA in the epiblast are stably committed to the skeletal muscle lineage.The Journal of cell biology · 2007Article
- A role for Insulin-like growth factor 2 in specification of the fast skeletal muscle fibre.BMC developmental biology · 2007Article
- MyoD-positive epiblast cells regulate skeletal muscle differentiation in the embryo.The Journal of cell biology · 2006Article
- Stable stem cell commitment to the adipocyte lineage by inhibition of DNA methylation: role of the BMP-4 gene.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Milieu-based versus gene-modulatory strategies for directing stem cell differentiation--A major issue of contention in transplantation medicine.In vitro cellular & developmental biology. AnimalArticle
- Acquired Resilience: An Evolved System of Tissue Protection in Mammals.Dose-response : a publication of International Hormesis SocietyReview
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Embryonic stem cells are derived from the epiblast. A subpopulation of epiblast cells expresses MyoD mRNA and the G8 antigen in vivo. G8 positive (G8pos) and G8 negative (G8neg) populations were isolated by magnetic cell sorting. Nearly all G8pos cells switched from E- to N-cadherin and differentiated into skeletal muscle in culture. G8neg cells were impaired in their ability to switch cadherins and few formed skeletal muscle. Medium conditioned by G8pos cells stimulated skeletal myogenesis and N-cadherin synthesis in G8neg cultures. The effect of conditioned medium from G8pos cultures was inhibited by bone morphogenetic protein (BMP) 4. Treatment of G8neg cells with a soluble form of the BMP receptor-IA or Noggin promoted N-cadherin synthesis and skeletal myogenesis. These results demonstrate that MyoD-positive epiblast cells recruit pluripotent cells to the skeletal muscle lineage. The mechanism of recruitment involves blocking the BMP signaling pathway.
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Registered trials
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