ArticleArthritis research & therapy2004
Novel approaches to gene expression analysis of active polyarticular juvenile rheumatoid arthritis.
Article in Arthritis research & therapy, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 105 citations in OpenAlex.
- A systematic strategy for identifying causal single nucleotide polymorphisms and their target genes on Juvenile arthritis risk haplotypes.BMC medical genomics · 2024Article
- Profiling the peripheral immune response to ex vivo TNF stimulation in untreated juvenile idiopathic arthritis using single cell RNA sequencing.Pediatric rheumatology online journal · 2023Article
- IRF1 governs the differential interferon-stimulated gene responses in human monocytes and macrophages by regulating chromatin accessibility.Cell reports · 2021Article
- Classification models using circulating neutrophil transcripts can detect unruptured intracranial aneurysm.Journal of translational medicine · 2020Article
- Biomarkers from circulating neutrophil transcriptomes have potential to detect unruptured intracranial aneurysms.Journal of translational medicine · 2018Article
- Modeling Transcriptional Rewiring in Neutrophils Through the Course of Treated Juvenile Idiopathic Arthritis.Scientific reports · 2018Article
- Article
- Using Chromatin Architecture to Understand the Genetics and Transcriptomics of Juvenile Idiopathic Arthritis.Frontiers in immunology · 2018Review
- Complexity and Specificity of the Neutrophil Transcriptomes in Juvenile Idiopathic Arthritis.Scientific reports · 2016Article
- Mitochondrial and oxidative stress genes are differentially expressed in neutrophils of sJIA patients treated with tocilizumab: a pilot microarray study.Pediatric rheumatology online journal · 2016Article
- RNA sequencing from human neutrophils reveals distinct transcriptional differences associated with chronic inflammatory states.BMC medical genomics · 2015Article
- Common and specific signatures of gene expression and protein-protein interactions in autoimmune diseases.Genes and immunity · 2013Article
- Correlation of cytokine levels and microglial cell infiltration during retinal degeneration in RCS rats.PloS one · 2013Article
- Evidence of dynamically dysregulated gene expression pathways in hyperresponsive B cells from African American lupus patients.PloS one · 2013Article
- Article
- Internal standard-based analysis of microarray data2--analysis of functional associations between HVE-genes.Nucleic acids research · 2011Article
- Protein array diagnostics for guiding therapy in rheumatoid arthritis.Molecular diagnosis & therapy · 2011Review
- Idiopathic inflammatory myopathies, signified by distinctive peripheral cytokines, chemokines and the TNF family members B-cell activating factor and a proliferation inducing ligand.Rheumatology (Oxford, England) · 2010Article
- Functional genomics and rheumatoid arthritis: where have we been and where should we go?Genome medicine · 2010Article
- Biologic predictors of extension of oligoarticular juvenile idiopathic arthritis as determined from synovial fluid cellular composition and gene expression.Arthritis and rheumatism · 2010Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Juvenile rheumatoid arthritis (JRA) has a complex, poorly characterized pathophysiology. Modeling of transcriptosome behavior in pathologic specimens using microarrays allows molecular dissection of complex autoimmune diseases. However, conventional analyses rely on identifying statistically significant differences in gene expression distributions between patients and controls. Since the principal aspects of disease pathophysiology vary significantly among patients, these analyses are biased. Genes with highly variable expression, those most likely to regulate and affect pathologic processes, are excluded from selection, as their distribution among healthy and affected individuals may overlap significantly. Here we describe a novel method for analyzing microarray data that assesses statistically significant changes in gene behavior at the population level. This method was applied to expression profiles of peripheral blood leukocytes from a group of children with polyarticular JRA and healthy control subjects. Results from this method are compared with those from a conventional analysis of differential gene expression and shown to identify discrete subsets of functionally related genes relevant to disease pathophysiology. These results reveal the complex action of the innate and adaptive immune responses in patients and specifically underscore the role of IFN-gamma in disease pathophysiology. Discriminant function analysis of data from a cohort of patients treated with conventional therapy identified additional subsets of functionally related genes; the results may predict treatment outcomes. While data from only 9 patients and 12 healthy controls was used, this preliminary investigation of the inflammatory genomics of JRA illustrates the significant potential of utilizing complementary sets of bioinformatics tools to maximize the clinical relevance of microarray data from patients with autoimmune disease, even in small cohorts.
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Registered trials
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