ArticleBreast cancer research : BCR2004
Relationship of cell proliferation (Ki-67) to 99mTc-(V)DMSA uptake in breast cancer.
Article in Breast cancer research : BCR, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 43 citations in OpenAlex.
- Imaging in situ breast carcinoma (with or without an invasive component) with technetium-99m pentavalent dimercaptosuccinic acid and technetium-99m 2-methoxy isobutyl isonitrile scintimammography.Breast cancer research : BCR · 2005Trial
- Correlations between Tumor to Background Ratio on Breast-Specific Gamma Imaging and Prognostic Factors in Breast Cancer.Journal of Korean medical science · 2017Article
- Nuclear imaging of the breast: translating achievements in instrumentation into clinical use.Medical physics · 2013Review
- Assessment of tracer 99mTc(V)-DMSA uptake as a measure of tumor cell proliferation in vitro.PloS one · 2013Article
- Reduced uptake of the proliferation-seeking radiotracer technetium-99m-labelled pentavalent dimercaptosuccinic acid in a 47-year-old woman with severe breast epithelial hyperplasia taking ibuprofen: a case report.Journal of medical case reports · 2010Article
- Nuclear imaging in cardiac amyloidosis.European journal of nuclear medicine and molecular imaging · 2009Review
- (99m)Tc-Tetrofosmin brain SPECT in the assessment of meningiomas-correlation with histological grade and proliferation index.Journal of neuro-oncology · 2008Article
- Role of 99mTc-(V)DMSA in detecting tumor cell proliferation.Analytical chemistry insights · 2007Article
- Pentavalent technetium-99m dimercaptosuccinic acid [99m Tc-(V)DMSA] brain scintitomography--a plausible non-invasive depicter of glioblastoma proliferation and therapy response.Journal of neuro-oncology · 2007Article
- Influence of Pi3-K and PKC activity on 99mTc-(V)-DMSA uptake: correlation with tumour aggressiveness in an in vitro malignant glioblastoma cell line model.European journal of nuclear medicine and molecular imaging · 2006Article
- Cellular uptake of (99m)TcN-NOET in human leukaemic HL-60 cells is related to calcium channel activation and cell proliferation.European journal of nuclear medicine and molecular imaging · 2006Article
- In vitro verification of the correlation of in vivo 99mTc-(V)DMSA uptake with cellular proliferation rate.European journal of nuclear medicine and molecular imaging · 2005Article
- Correlation between 99mTc-(V)-DMSA uptake and constitutive level of phosphorylated focal adhesion kinase in an in vitro model of cancer cell lines.European journal of nuclear medicine and molecular imaging · 2005Article
- Dimercaptosuccinic acid: A multifunctional cost effective agent for imaging and therapy.Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, IndiaReview
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13 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
introductionThe aim of the present study was to identify the relationships between the uptake of radiotracers - namely pentavalent dimercaptosuccinic acid [(V)DMSA] and sestamibi (MIBI) - and the following parameters in primary breast cancer: steroid receptor concentrations (i.e. estrogen receptor [ER] and progesterone receptor [PR]), Ki-67 expression, tumor size, tumor grade, age, and levels of expression of p53 and c-erbB-2. In addition, by multivariate regression analysis, we further isolated those factors with independent associations with (V)DMSA and/or MIBI uptake in primary breast cancer.
methodsThirty-four patients with histologically confirmed breast carcinoma underwent preoperative scintimammography with technetium-99m (99mTc)-(V)DMSA and/or 99mTc-MIBI in consecutive sessions 10 and 60 min after administration of 925-1110 MBq of each radiotracer. The tumor-to-background ratio was calculated and correlated with the presence of ER, PR, Ki-67, tumor size, tumor grade, p53, and c-erbB-2. ER, PR, p53, and c-erbB-2 were determined immunohistochemically. The analysis included tumor-to-background ratio of (V)DMSA and MIBI uptake as dependent and all of the other parameters as independent variables.
resultsCorrelation was positive between Ki-67 and (V)DMSA (r = 0.37 at 10 min, P = 0.038; r = 0.42 at 60 min, P = 0.018) and inverse between PR and (V)DMSA uptake (r = -0.46 at 10 min, P = 0.010; r = -0.51 at 60 min, P = 0.003). Multivariate regression analysis demonstrated a positive correlation between Ki-67 and (V)DMSA at 60 min (P = 0.045). Ki-67 was not significantly correlated with MIBI uptake, whereas tumor size was positively correlated with MIBI uptake at 60 min both in univariate (r = 0.45, P = 0.027) and multivariate analysis (P = 0.024). Negative correlations were observed between (V)DMSA uptake and ER, as well as between ER/PR and MIBI uptake, but these were not significant.
conclusionKi-67 appears to represent the major independent factor affecting (V)DMSA uptake in breast cancer. Tumor size was the only independent parameter influencing MIBI uptake in breast cancer. (V)DMSA appears to have an advantage over MIBI in that it can be used to visualize tumors with intense proliferative activity, and thus it can identify those tumors that are more aggressive.
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