ReviewInternational journal of hematology2004
Plasticity of human stem cells in the fetal sheep model of human stem cell transplantation.
Review in International journal of hematology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Efficient derivation of stable sheep embryonic stem cells opens a new avenue for agricultural and biomedical application.Journal of advanced research · 2026Article
- Hemophilia A: An Ideal Disease for Prenatal Therapy.Prenatal diagnosis · 2025Review
- Is chimerism associated with cancer across the tree of life?PloS one · 2023Article
- Molecular Mechanisms of Fetal Tendon Regeneration Versus Adult Fibrous Repair.International journal of molecular sciences · 2021Article
- Large Animal Models in Regenerative Medicine and Tissue Engineering: To Do or Not to Do.Frontiers in bioengineering and biotechnology · 2020Review
- Fetal articular cartilage regeneration versus adult fibrocartilaginous repair: secretome proteomics unravels molecular mechanisms in an ovine model.Disease models & mechanisms · 2018Article
- In utero stem cell transplantation and gene therapy: rationale, history, and recent advances toward clinical application.Molecular therapy. Methods & clinical development · 2016Review
- Hemophilia A: an ideal disease to correct in utero.Frontiers in pharmacology · 2014Review
- Article
- Treatment of Hemophilia A in Utero and Postnatally using Sheep as a Model for Cell and Gene Delivery.Journal of genetic syndromes & gene therapy · 2012Article
- Phenotypic correction of hemophilia A in sheep by postnatal intraperitoneal transplantation of FVIII-expressing MSC.Experimental hematology · 2011Article
- Mesenchymal stem cells as therapeutics and vehicles for gene and drug delivery.Advanced drug delivery reviews · 2010Review
- Bone marrow stem cells and liver regeneration.Experimental hematology · 2010Review
- Generation of tissue-specific cells from MSC does not require fusion or donor-to-host mitochondrial/membrane transfer.Stem cell research · 2009Article
- Mesenchymal stem cells in cancer: tumor-associated fibroblasts and cell-based delivery vehicles.International journal of hematology · 2007Review
- Suppression of prion protein in livestock by RNA interference.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Gene therapy progress and prospects: stem cell plasticity.Gene therapy · 2005Review
- Issues in stem cell plasticity.Journal of cellular and molecular medicineReview
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Experimental models that allow the evaluation of the full potential of stem cells under normal physiological conditions and in the absence of genetic or injury-induced dysfunction would serve as valuable tools for the study of the mechanisms underlying stem cell differentiation. Ideally, such a model would also permit the robust formation of donor-derived tissue-specific cells. Because studies have shown that the differentiation of stem cells into cells of a different germinal layer is highly inefficient in the absence of selective pressure, it is very unlikely that a healthy adult animal can fulfill these requirements. In this review, we describe the advantages of the permissive aspects of the developing preimmune fetus in the early gestational age that led us to develop the sheep as a large-animal model of human stem cell plasticity.
Indexed as
Identifiers
14979471What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.