ArticleThe Journal of physiology2004
Subtypes of vagal afferent C-fibres in guinea-pig lungs.
Article in The Journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers, 1 of them a synthesis that pooled it.
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Who cites it
114 citing papers in PubMed, 1 synthesis or guideline pooled it, 253 citations in OpenAlex.
- Pooled it
- Blockade of airway sensory nerves and dyspnea in humans.Pulmonary pharmacology & therapeutics · 2010Trial
- Reflex regulation of respiration and heart rate by inhaled activators of vagal bronchopulmonary afferents.Journal of neurophysiology · 2025Article
- Brainstem opioid peptidergic neurons regulate cough reflexes in mice.Innovation (Cambridge (Mass.)) · 2024Article
- Review
- Role of NaThe Journal of physiology · 2023Article
- Variability in P2X receptor composition in human taste nerves: implications for treatment of chronic cough.ERJ open research · 2023Article
- Transformation of Our Understanding of Breathing Control by Molecular Tools.Annual review of physiology · 2023Review
- Irritant-evoked reflex tachyarrhythmia in spontaneously hypertensive rats is reduced by inhalation of TRPM8 agonists l-menthol and WS-12.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- ATP, an attractive target for the treatment of refractory chronic cough.Purinergic signalling · 2022Review
- Treatment with the P2X3-Receptor Antagonist Gefapixant for Acute Cough in Induced Viral Upper Respiratory Tract Infection: A Phase 2a, Randomized, Placebo-Controlled Trial.Pulmonary therapy · 2022Article
- Strategies for precision vagus neuromodulation.Bioelectronic medicine · 2022Review
- Role of NaBritish journal of pharmacology · 2022Article
- Mechanosensitivity of Murine Lung Slowly Adapting Receptors: Minimal Impact of Chemosensory, Serotonergic, and Purinergic Signaling.Frontiers in physiology · 2022Article
- Neural control of the lower airways: Role in cough and airway inflammatory disease.Handbook of clinical neurology · 2022Review
- Intralaryngeal application of ATP evokes apneic response mainly via acting on P2X3 (P2X2/3) receptors of the superior laryngeal nerve in postnatal rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- The Changes in Expression of NaMembranes · 2021Article
- Altered physiology of gastrointestinal vagal afferents following neurotrauma.Neural regeneration research · 2021Review
- Molecular identity, anatomy, gene expression and function of neural crest vs. placode-derived nociceptors in the lower airways.Neuroscience letters · 2021Review
- The Cough Reflex: The Janus of Respiratory Medicine.Frontiers in physiology · 2021Review
54 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An ex vivo, vagally innervated, lung preparation was used to address the hypothesis that vagal C-fibres comprise at least two distinct phenotypes. Histological and extracellular electrophysiological experiments revealed that vagal C-fibres innervating the pulmonary system are derived from cell bodies situated in two distinct vagal sensory ganglia. The jugular (superior) ganglion neurones project C-fibres to both the extrapulmonary airways (larynx, trachea and bronchus) and the lung parenchymal tissue. By contrast, C-fibres from nodose (inferior) neurones innervate primarily structures within the lungs. Histologically, nodose neurones projecting lung C-fibres were different from the jugular neurones in that they were significantly less likely to express neurokinins. The nerve terminals within the lungs of both nodose and jugular C-fibres responded with action potential discharge to capsaicin and bradykinin application, but only the nodose C-fibre population responded with action potential discharge to the P2X selective receptor agonist alpha,beta-methylene-ATP. Whole cell patch clamp recording of capsaicin-sensitive nodose and jugular ganglion neurones retrogradely labelled from the lung tissue revealed that, like the nerve terminals, lung specific nodose C-fibre neurones express functional P2X receptors, whereas lung specific jugular C-fibres do not. The data support the hypothesis that both neural crest-derived neurones (jugular ganglia) and placode-derived neurones (nodose ganglia) project C-fibres in the vagus, and that these two C-fibre populations represent distinct phenotypes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.