ArticleInfection and immunity2004
Identification of srv, a PrfA-like regulator of group A streptococcus that influences virulence.
Article in Infection and immunity, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- High-quality draft genome of the Listeria monocytogenes, one more vaccine strain against livestock listeriosis.Scientific data · 2026Article
- Review
- Streptococcus pyogenes biofilms-formation, biology, and clinical relevance.Frontiers in cellular and infection microbiology · 2015Review
- Enantioselective regulation of lactate racemization by LarR in Lactobacillus plantarum.Journal of bacteriology · 2015Article
- Dispersal of Group A streptococcal biofilms by the cysteine protease SpeB leads to increased disease severity in a murine model.PloS one · 2011Article
- Srv mediated dispersal of streptococcal biofilms through SpeB is observed in CovRS+ strains.PloS one · 2011Article
- Allelic replacement of the streptococcal cysteine protease SpeB in a Δsrv mutant background restores biofilm formation.BMC research notes · 2010Article
- Loss of the group A Streptococcus regulator Srv decreases biofilm formation in vivo in an otitis media model of infection.Infection and immunity · 2010Article
- Generation of metabolically diverse strains of Streptococcus pyogenes during survival in stationary phase.Journal of bacteriology · 2009Article
- Streptococcus adherence and colonization.Microbiology and molecular biology reviews : MMBR · 2009Review
- Biofilm formation by group A Streptococcus: a role for the streptococcal regulator of virulence (Srv) and streptococcal cysteine protease (SpeB).Microbiology (Reading, England) · 2009Article
- An AraC-type transcriptional regulator encoded on the Enterococcus faecalis pathogenicity island contributes to pathogenesis and intracellular macrophage survival.Infection and immunity · 2008Article
- Functional analysis of the group A streptococcal luxS/AI-2 system in metabolism, adaptation to stress and interaction with host cells.BMC microbiology · 2008Article
- Characterization of the Ers regulon of Enterococcus faecalis.Infection and immunity · 2008Article
- Point mutations within the streptococcal regulator of virulence (Srv) alter protein-DNA interactions and Srv function.Microbiology (Reading, England) · 2008Article
- Inactivation of the group A Streptococcus regulator srv results in chromosome wide reduction of transcript levels, and changes in extracellular levels of Sic and SpeB.FEMS immunology and medical microbiology · 2006Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have identified a Crp/Fnr-like transcriptional regulator of Streptococcus pyogenes that when inactivated attenuates virulence. The gene, named srv for streptococcal regulator of virulence, encodes a 240-amino-acid protein with 53% amino acid similarity to PrfA, a transcriptional activator of virulence in Listeria monocytogenes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.