ArticleInfection and immunity2004
Characterization of oral Yersinia enterocolitica infection in three different strains of inbred mice.
Article in Infection and immunity, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 51 citations in OpenAlex.
- Review
- Article
- Characterization of blue light irradiation effects on pathogenic and nonpathogenic Escherichia coli.MicrobiologyOpen · 2017Article
- Nod2: The intestinal gate keeper.PLoS pathogens · 2017Review
- LuxCDE-luxAB-based promoter reporter system to monitor the Yersinia enterocolitica O:3 gene expression in vivo.PloS one · 2017Article
- Infectious etiopathogenesis of Crohn's disease.World journal of gastroenterology · 2014Review
- Yersinia pseudotuberculosis efficiently escapes polymorphonuclear neutrophils during early infection.Infection and immunity · 2014Article
- YaxAB, a Yersinia enterocolitica pore-forming toxin regulated by RovA.Infection and immunity · 2013Article
- Role of YopK in Yersinia pseudotuberculosis resistance against polymorphonuclear leukocyte defense.Infection and immunity · 2013Article
- Yersinia pseudotuberculosis disrupts intestinal barrier integrity through hematopoietic TLR-2 signaling.The Journal of clinical investigation · 2012Article
- In vivo-induced InvA-like autotransporters Ifp and InvC of Yersinia pseudotuberculosis promote interactions with intestinal epithelial cells and contribute to virulence.Infection and immunity · 2012Article
- Host innate recognition of an intestinal bacterial pathogen induces TRIF-dependent protective immunity.The Journal of experimental medicine · 2011Article
- Unique cell adhesion and invasion properties of Yersinia enterocolitica O:3, the most frequent cause of human Yersiniosis.PLoS pathogens · 2011Article
- Pathogenesis of Y. enterocolitica and Y. pseudotuberculosis in Human Yersiniosis.Journal of pathogens · 2011Article
- Transforming growth factor beta and CD25 are important for controlling systemic dissemination following Yersinia enterocolitica infection of the gut.Infection and immunity · 2010Article
- YopH inhibits early pro-inflammatory cytokine responses during plague pneumonia.BMC immunology · 2010Article
- Innate immune response during Yersinia infection: critical modulation of cell death mechanisms through phagocyte activation.Journal of leukocyte biology · 2009Review
- YspM, a newly identified Ysa type III secreted protein of Yersinia enterocolitica.Journal of bacteriology · 2008Article
- The resistance of BALB/cJ mice to Yersinia pestis maps to the major histocompatibility complex of chromosome 17.Infection and immunity · 2008Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Several studies have highlighted differences in the resistances of various mouse strains to intravenous (i.v.) infection with Yersinia enterocolitica. In particular, differences in resistance and immunological response between BALB/c and C57BL/6 mouse strains have been determined. Following i.v infection, C57BL/6 mice are more resistant to Y. enterocolitica than are BALB/c mice. However, because Y. enterocolitica is typically a food-borne pathogen, the oral route of infection more accurately reflects the natural route of infection. Therefore, it was of interest to ascertain if the differences in resistance between mouse strains observed for an i.v. infection can be recapitulated following an oral infection. C57BL/6j, BALB/cj, and 129X1/Svj mouse strains presented no differences in 50% lethal dose (LD(50)) following oral infection with Y. enterocolitica. Subsequent analysis of cytokine levels, bacterial colonization and immune cell populations following oral infection confirmed characteristics previously described following i.v. Y. enterocolitica infection. All tissues analyzed from each mouse strain demonstrated a polarized Th1 cytokine profile and inflammatory cell influx throughout a 7-day course of infection. This immune response was present in all tissues and increased as bacterial colonization progressed. The lack of a differing LD(50) phenotype and common trends in immunological response among the three mouse strains tested suggests that oral infection is a useful model for studying the host response to Y. enterocolitica infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.