ArticleInfection and immunity2004
Blockade of endogenous leukotrienes exacerbates pulmonary histoplasmosis.
Article in Infection and immunity, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 120 citations in OpenAlex.
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- Leukotrienes in Innate Immunity: Still Underappreciated after All These Years?Journal of immunology (Baltimore, Md. : 1950) · 2023Review
- Toxoplasma gondii Infection Decreases Intestinal 5-Lipoxygenase Expression, while Exogenous LTBInfection and immunity · 2022Article
- Complex and Controversial Roles of Eicosanoids in Fungal Pathogenesis.Journal of fungi (Basel, Switzerland) · 2021Review
- CircPlekha7 plays an anti-fibrotic role in intrauterine adhesions by modulating endometrial stromal cell proliferation and apoptosis.The Journal of reproduction and development · 2020Article
- Rhipicephalus microplus serpins interfere with host immune responses by specifically modulating mast cells and lymphocytes.Ticks and tick-borne diseases · 2020Article
- IL-22 Promotes IFN-γ-Mediated Immunity againstBiomolecules · 2020Article
- The Role of NLRP3 Inflammasome Activation in the Epithelial to Mesenchymal Transition Process During the Fibrosis.Frontiers in immunology · 2020Review
- Aedes aegypti saliva impairs M1-associated proinflammatory phenotype without promoting or affecting M2 polarization of murine macrophages.Parasites & vectors · 2019Article
- Flying under the radar: Histoplasma capsulatum avoidance of innate immune recognition.Seminars in cell & developmental biology · 2019Review
- Prostaglandins DJournal of lipid research · 2018Article
- Leukotriene BScientific reports · 2017Article
- Host-Derived Leukotriene BFrontiers in immunology · 2017Article
- Cytosolic phospholipase A2 contributes to innate immune defense against Candida albicans lung infection.BMC immunology · 2016Article
- TGF-β/SMAD Pathway and Its Regulation in Hepatic Fibrosis.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2016Review
- Opposing roles of LTB4 and PGE2 in regulating the inflammasome-dependent scorpion venom-induced mortality.Nature communications · 2016Article
- Protective Effect of Galectin-1 duringMediators of inflammation · 2016Article
- Mononuclear phagocyte-mediated antifungal immunity: the role of chemotactic receptors and ligands.Cellular and molecular life sciences : CMLS · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leukotrienes are classical mediators of inflammatory response. New aspects of leukotriene function have recently been described. We examine here the previously unreported role that leukotrienes play in the regulation of cytokines in a murine model of histoplasmosis. We demonstrate that administration of MK 886, a leukotriene synthesis inhibitor, caused Histoplasma capsulatum-infected mice to die by the day 15 of infection, whereas the correlating death rate in untreated infected mice was 0%. Treating infected animals with MK 886 inhibited leukotriene synthesis but increased leukocyte recruitment to the lungs. Subsequent to this phenomenon, levels of tumor necrosis factor alpha, interleukin-1 (IL-1), IL-6, and KC chemoattractant cytokines and fungi in the lung parenchyma increased, as did inflammatory response. In contrast, IL-2, IL-5, IL-12, and gamma interferon cytokine levels actually decreased. Thus, murine response to pulmonary histoplasmosis may be leukotriene modulated. This finding may enable us to alter the course of the immune response and inflammation caused by histoplasmosis. The data from the present study suggest an important new strategy for immunologic or drug intervention in human patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.