ArticleInfection and immunity2004
Helicobacter pylori and complex gangliosides.
Article in Infection and immunity, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 61 citations in OpenAlex.
- Pathogenicity and virulence ofVirulence · 2025Review
- Beyond the stomach: the association betweenFrontiers in cellular and infection microbiology · 2025Review
- Review
- Sialic Acids as Receptors for Pathogens.Biomolecules · 2021Review
- Article
- Glycosphingolipids Recognized byMicroorganisms · 2020Article
- Review
- Review
- The Role of Glycosphingolipids in Immune Cell Functions.Frontiers in immunology · 2019Review
- Helicobacter suis binding to carbohydrates on human and porcine gastric mucins and glycolipids occurs via two modes.Virulence · 2018Article
- Helicobacter pylori SabA binding gangliosides of human stomach.Virulence · 2018Article
- Helicobacter pylori chronic infection and mucosal inflammation switches the human gastric glycosylation pathways.Biochimica et biophysica acta · 2015Article
- Molecular recognition of gangliosides and their potential for cancer immunotherapies.Frontiers in immunology · 2014Review
- Article
- Ganglioside biochemistry.ISRN biochemistry · 2012Review
- Molecular mechanisms of gastric epithelial cell adhesion and injection of CagA by Helicobacter pylori.Cell communication and signaling : CCS · 2011Article
- Expression of the Helicobacter pylori adhesin SabA is controlled via phase variation and the ArsRS signal transduction system.Microbiology (Reading, England) · 2008Article
- Increasing evidence of the role of Helicobacter pylori SabA in the pathogenesis of gastroduodenal disease.Journal of infection in developing countries · 2008Review
- SabA is the H. pylori hemagglutinin and is polymorphic in binding to sialylated glycans.PLoS pathogens · 2006Article
- Pathogenesis of Helicobacter pylori infection.Clinical microbiology reviews · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recognition of sialic acid-containing glycoconjugates by the human gastric pathogen Helicobacter pylori has been repeatedly demonstrated. To investigate the structural requirements for H. pylori binding to complex gangliosides, a large number of gangliosides were isolated and characterized by mass spectrometry and proton nuclear magnetic resonance. Ganglioside binding of sialic acid-recognizing H. pylori strains (strains J99 and CCUG 17874) and knockout mutant strains with the sialic acid binding adhesin SabA or the NeuAcalpha3Galbeta4GlcNAcbeta3Galbeta4GlcNAcbeta-binding neutrophil-activating protein HPNAP deleted was investigated using the thin-layer chromatogram binding assay. The wild-type bacteria bound to N-acetyllactosamine-based gangliosides with terminal alpha3-linked NeuAc, while gangliosides with terminal NeuGcalpha3, NeuAcalpha6, or NeuAcalpha8NeuAcalpha3 were not recognized. The factors affecting binding affinity were identified as (i) the length of the N-acetyllactosamine carbohydrate chain, (ii) the branches of the carbohydrate chain, and (iii) fucose substitution of the N-acetyllactosamine core chain. While the J99/NAP(-) mutant strain displayed a ganglioside binding pattern identical to that of the parent J99 wild-type strain, no ganglioside binding was obtained with the J99/SabA(-) mutant strain, demonstrating that the SabA adhesin is the sole factor responsible for the binding of H. pylori bacterial cells to gangliosides.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.