ArticleGenes & development2004
Nucleolar protein PinX1p regulates telomerase by sequestering its protein catalytic subunit in an inactive complex lacking telomerase RNA.
Article in Genes & development, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 67 citations in OpenAlex.
- Post-Transcriptional and Post-Translational Modifications in Telomerase Biogenesis and Recruitment to Telomeres.International journal of molecular sciences · 2023Review
- Defining the Functional Interactome of Spliceosome-Associated G-Patch Protein Gpl1 in the Fission YeastInternational journal of molecular sciences · 2022Article
- Hesperidin Inhibits Lung CancerFrontiers in pharmacology · 2022Article
- The PinX1/NPM interaction associates with hTERT in early-S phase and facilitates telomerase activation.Cell & bioscience · 2019Article
- Article
- PinX1: structure, regulation and its functions in cancer.Oncotarget · 2016Review
- Biological significance of PinX1 telomerase inhibitor in esophageal carcinoma treatment.Experimental and therapeutic medicine · 2016Article
- Article
- Protein cofactor competition regulates the action of a multifunctional RNA helicase in different pathways.RNA biology · 2016Article
- Article
- Increased Stability of Nucleolar PinX1 in the Presence of TERT.Molecules and cells · 2015Article
- The telomerase inhibitor Gno1p/PINX1 activates the helicase Prp43p during ribosome biogenesis.Nucleic acids research · 2014Article
- Article
- Gene overexpression: uses, mechanisms, and interpretation.Genetics · 2012Review
- Telomerase regulation.Mutation research · 2012Review
- Article
- PinX1 the tail on the chromosome.The Journal of clinical investigation · 2011Article
- The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in mice.The Journal of clinical investigation · 2011Article
- Telomerase inhibitor PinX1 provides a link between TRF1 and telomerase to prevent telomere elongation.The Journal of biological chemistry · 2011Article
- Spp382p interacts with multiple yeast splicing factors, including possible regulators of Prp43 DExD/H-Box protein function.Genetics · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Human TRF1-binding protein PinX1 inhibits telomerase activity. Here we report that overexpression of yeast PinX1p (yPinX1p) results in shortened telomeres and decreased in vitro telomerase activity. yPinX1p coimmunoprecipitated with yeast telomerase protein Est2p even in cells lacking the telomerase RNA TLC1, or the telomerase-associated proteins Est1p and Est3p. Est2p regions required for binding to yPinX1p or TLC1 were similar. Furthermore, we found two distinct Est2p complexes exist, containing either yPinX1p or TLC1. Levels of Est2p-yPinX1p complex increased when TLC1 was deleted and decreased when TLC1 was overexpressed. Hence, we propose that yPinX1p regulates telomerase by sequestering its protein catalytic subunit in an inactive complex lacking telomerase RNA.
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Registered trials
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