ArticleThe British journal of ophthalmology2004
Systemic CD4(+) T cell phenotype and activation status in intermediate uveitis.
Article in The British journal of ophthalmology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 45 citations in OpenAlex.
- Clinical characteristics and treatment of pars planitis: an adalimumab experience.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022Article
- Immunopathophysiology and clinical impact of uveitis in inflammatory rheumatic diseases: An update.European journal of clinical investigation · 2021Review
- New pharmacotherapy options for noninfectious posterior uveitis.International ophthalmology · 2021Review
- Imbalance in PB IL-17-Secreting and Regulatory Cells in Pars Planitis Is Associated with Dysregulation of IFN-Mediators of inflammation · 2020Article
- Immunopathogenic Background of Pars Planitis.Archivum immunologiae et therapiae experimentalis · 2016Review
- Article
- Current concepts and future directions in the pathogenesis and treatment of non-infectious intraocular inflammation.Eye (London, England) · 2012Review
- Intraocular and serum cytokine profiles in patients with intermediate uveitis.Molecular vision · 2011Article
- Retinal S-antigen Th1 cell epitope mapping in patients with Behcet's disease.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2009Article
- LX211 (voclosporin) suppresses experimental uveitis and inhibits human T cells.Investigative ophthalmology & visual science · 2009Article
- Pars planitis is associated with an increased frequency of effector-memory CD57+ T cells.The British journal of ophthalmology · 2007Article
- Cytokines and chemokines in uveitis: is there a correlation with clinical phenotype?Clinical medicine & research · 2006Review
- Pathogenesis of Uveitic Glaucoma.Journal of current glaucoma practiceReview
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate peripheral blood lymphocyte phenotype in patients with intermediate uveitis using CD69, chemokine receptor, and cytokine expression.
methodsPeripheral blood lymphocytes of 18 patients with idiopathic intermediate uveitis and 6 patients with presumed sarcoid intermediate uveitis were evaluated for CD4(+) T cell expression of CD69, CCR4, CCR5, CXCR3 and the intracellular cytokines IFNgamma, TNFalpha, and interleukin (IL)-10 by flow cytometry, and for IL-2, IL-4, IL-5, IL-10, IFNgamma, and TNFalpha production following unstimulated and activated culture using cytokine bead array and compared with healthy control subjects.
resultsThe expression of CD69 and TNFalpha by peripheral blood CD4(+) lymphocytes of patients with idiopathic intermediate uveitis and presumed sarcoid intermediate uveitis was significantly higher than control subjects (p = 0.002 and p<0.05, respectively). The ratios of the concentrations of IL-2:IL-5 and IFNgamma:IL-5 in supernatants of activated peripheral blood lymphocyte cultures were significantly higher in patients with presumed sarcoid intermediate uveitis than control subjects.
conclusionsThis study implicates TNFalpha in the pathogenesis of intermediate uveitis, highlighting the potential role of anti-TNF treatments for this disease. Studies of Th1:Th2 cytokine ratios suggested polarisation of the immune response towards Th1 in presumed sarcoid intermediate uveitis despite clinically quiescent systemic disease.
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