Trial reportThe British journal of ophthalmology2004
Ocular haemodynamic responses to induced hypercapnia and hyperoxia in glaucoma.
Trial report in The British journal of ophthalmology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01325285 (The Response of Intraocular Pressure to Systemic Hypercapnia and Hyperoxia), which is not on this map. Cited by 28 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Response of Intraocular Pressure to Systemic Hypercapnia and Hyperoxia
Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- A deep dive into hyperbaric environments and intraocular pressure-a systematic review.Frontiers in medicine · 2024Pooled it
- Ocular Perfusion Pressure and the Risk of Open-Angle Glaucoma: Systematic Review and Meta-analysis.Scientific reports · 2020Pooled it
- Color Doppler imaging analysis of retrobulbar blood flow velocities in primary open-angle glaucomatous eyes: a meta-analysis.PloS one · 2013Pooled it
- The additive effect of dorzolamide hydrochloride (Trusopt) and a morning dose of bimatoprost (Lumigan) on intraocular pressure and retrobulbar blood flow in patients with primary open-angle glaucoma.The British journal of ophthalmology · 2010Trial
- Comparison of the number of peripapillary perforating scleral vessels between glaucomatous eyes and healthy eyes.Scientific reports · 2025Article
- pH in the vertebrate retina and its naturally occurring and pathological changes.Progress in retinal and eye research · 2025Review
- Measurement of Retrobulbar Blood Flow and Vascular Reactivity-Relevance for Ocular and Cardiovascular Diseases.Diagnostics (Basel, Switzerland) · 2023Review
- Vasoreactivity of the optic nerve head, nailfold, and facial skin in response to cold provocation in normal-tension glaucoma patients.BMC ophthalmology · 2023Article
- Metabolic blood flow regulation in a hybrid model of the human retinal microcirculation.Mathematical biosciences · 2023Article
- Evidence of vascular involvement in myopia: a review.Frontiers in medicine · 2023Review
- Retinal microcirculation characteristics in obstructive sleep apnea/hypopnea syndrome evaluated by OCT-angiography: a literature review.International ophthalmology · 2022Review
- A Pilot Study Assessing Retinal Blood Flow Dysregulation in Glaucoma Using Erythrocyte Mediated Velocimetry.Translational vision science & technology · 2022Article
- Association of Neuroretinal Thinning and Microvascular Changes with Hypertension in an Older Population in Southern Italy.Journal of clinical medicine · 2022Article
- Effects of chronic mild hyperoxia on retinal and choroidal blood flow and retinal function in the DBA/2J mouse model of glaucoma.PloS one · 2022Article
- Retinal Microcirculatory Responses to Hyperoxia in Primary Open-Angle Glaucoma Using Optical Coherence Tomography Angiography.Investigative ophthalmology & visual science · 2021Article
- Evaluation of retinal vessel density and foveal avascular zone measurements in patients with obstructive sleep apnea syndrome.International ophthalmology · 2021Article
- Retinal vascular impairment in patients newly diagnosed with obstructive sleep apnea syndrome.Multidisciplinary respiratory medicine · 2021Article
- Enhanced Physiological Stress Response in Patients with Normal Tension Glaucoma during Hypoxia.Journal of ophthalmology · 2021Article
- Effects of fentanyl on intraocular pressure and pupil size in medetomidine-methadone premedicated dogs: a pilot study.Veterinary record open · 2020Article
- Hypercapnia Impairs Vasoreactivity to Changes in Blood Pressure and Intraocular Pressure in Rat Retina.Optometry and vision science : official publication of the American Academy of Optometry · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
aimTo determine the ocular haemodynamic response to gas perturbations in glaucoma.
methodsIntraocular pressure (IOP), systemic systolic and diastolic blood pressure (SBP and DBP), and retrobulbar blood flow velocities, measured by colour Doppler imaging (CDI), were recorded at two visits. CDI was used to measure peak systolic and end diastolic velocities (PSV and EDV) and resistance index (RI) in the ophthalmic artery (OA), central retinal artery (CRA), and short posterior ciliary arteries (SPCAs). At the first visit, measurements were taken at baseline (B1: breathing room air) and during isoxic hypercapnia (end tidal PCO(2) increased 15% above baseline) in 16 normal subjects and 12 patients with glaucoma. On another day, measurements were repeated at a second baseline (B2) and during hyperoxia (100% oxygen breathing) for 15 normal subjects and 13 glaucoma patients. Baseline systemic data were compared using paired t tests; REANOVA was performed to compare group differences at baseline and to determine the vessel response to each condition. Fisher's LSD was used for post hoc comparison.
resultsBaseline OA PSV was lower for the glaucoma than for the normal group (p = 0.047); the groups were otherwise similar at baseline. IOP demonstrated no response to hypercapnia, but reduced during hyperoxia for both the normal subjects (p<0.0001) and glaucoma patients (p = 0.04). During hypercapnia, SBP increased in normal subjects (p = 0.03) and glaucoma patients (p = 0.01); DBP increased in normal subjects (p = 0.021). There was a corresponding increase in ocular perfusion pressure (OPP) for normal subjects (p = 0.01) and glaucoma subjects (p = 0.028), and as a result OPP was included as a covariate in the REANCOVA model. Hypercapnia resulted in increased PSV in the CRA of normal subjects (p = 0.035) and increased PSV and EDV in the SPCAs of glaucoma patients (p = 0.041 and p = 0.030 respectively). Hyperoxia resulted in reduced PSV and EDV in the ophthalmic arteries of normal subjects only (p = 0.001 and 0.031 respectively).
conclusionsThese findings suggest the presence of relative vasoconstriction in glaucoma patients, which is at least partially reversed by hypercapnia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.